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Tdark
ANKRD44
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B

Protein Summary
Description
Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282272
  • ENSP00000282272
  • ENSG00000065413
  • ENST00000328737
  • ENSP00000331516
  • ENST00000409153
  • ENSP00000387141
  • ENST00000409919
  • ENSP00000387233

Symbol
  • PP6-ARS-B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
trait
0.93
transcription factor perturbation
0.84
transcription factor binding site profile
0.78
transcription factor
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.89   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.89   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
PPP6R2
Tbio
Family:  Enzyme
Novelty:  0.12886225
p_int:  1
Score:  0.824
Data Source:  BioPlex,STRINGDB
NOTCH1
Tchem
Novelty:  0.00012547
p_int:  0.999999998
p_ni:  2e-9
Score:  0.309
Data Source:  BioPlex,STRINGDB
USP10
Tchem
Family:  Enzyme
Novelty:  0.05830541
p_int:  0.99999946
p_ni:  5.19e-7
p_wrong:  2e-8
Score:  0.705
Data Source:  BioPlex,STRINGDB
ANKRD28
Tbio
Family:  Enzyme
Novelty:  0.10895759
p_int:  0.99999888
p_ni:  0.00000112
Score:  0.697
Data Source:  BioPlex,STRINGDB
CDKN2C
Tbio
Family:  Enzyme
Novelty:  0.00806886
p_int:  0.999998875
p_ni:  0.000001125
Score:  0.264
Data Source:  BioPlex,STRINGDB
PPP6R1
Tbio
Family:  Enzyme
Novelty:  0.0388319
p_int:  0.999995272
p_ni:  0.000004728
Score:  0.891
Data Source:  BioPlex,STRINGDB
NOTCH2
Tchem
Novelty:  0.00195617
p_int:  0.999991275
p_ni:  0.000008725
Score:  0.274
Data Source:  BioPlex,STRINGDB
NOTCH3
Tchem
Novelty:  0.000953
p_int:  0.999915535
p_ni:  0.000084458
p_wrong:  7e-9
Score:  0.347
Data Source:  BioPlex,STRINGDB
TRMT2A
Tbio
Family:  Enzyme
Novelty:  0.15277091
p_int:  0.999884805
p_ni:  0.000115193
p_wrong:  2e-9
Score:  0.791
Data Source:  BioPlex,STRINGDB
PLK2
Tchem
Family:  Kinase
Novelty:  0.00750465
p_int:  0.999820724
p_ni:  0.00017916
p_wrong:  1.16e-7
Score:  0.492
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
2
1
2
79.4
brain measurement
1
1
0
16.6
75.8
cortical surface area measurement
1
1
0
10.7
68.2
BMI-adjusted waist-hip ratio
1
1
1
65.4
cortical thickness
1
1
0
9.5
64.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
2
79.4
brain measurement
0
16.6
75.8
cortical surface area measurement
0
10.7
68.2
BMI-adjusted waist-hip ratio
1
65.4
cortical thickness
0
9.5
64.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 2.89
PubMed score by year
PubTator Score 0.67
PubTator score by year
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Related Publications
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PMID
Year
Title