Tbio ANKRD26 Ankyrin repeat domain-containing protein 26

Protein Summary

Description

Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. This gene encodes a protein containing N-terminal ankyrin repeats which function in protein-protein interactions. Mutations in this gene are associated with autosomal dominant thrombocytopenia-2. Pseudogenes of this gene are found on chromosome 7, 10, 13 and 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Uniprot Accession IDs

• Q9UPS8
• A6NH29
• Q2TAZ3
• Q6ZR14
• Q9H1Q1
• Q9NSK9
• Q9NTD5
• Q9NW69

Gene Name

• ANKRD26

Ensembl ID

• ENST00000376087
• ENSP00000365255
• ENSG00000107890

Symbol

• KIAA1074
• THC2
• bA145E8.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.92
kinase perturbation	0.76
tissue sample	0.67
cell type or tissue	0.64
cell line	0.6

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.41   (req: < 5)

Gene RIFs: 28   (req: <= 3)

Antibodies: 110   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.41   (req: >= 5)

Gene RIFs: 28   (req: > 3)

Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0