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Tbio
ANKRD26
Ankyrin repeat domain-containing protein 26

Protein Summary
Description
Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior. This gene encodes a protein containing N-terminal ankyrin repeats which function in protein-protein interactions. Mutations in this gene are associated with autosomal dominant thrombocytopenia-2. Pseudogenes of this gene are found on chromosome 7, 10, 13 and 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376087
  • ENSP00000365255
  • ENSG00000107890

Symbol
  • KIAA1074
  • THC2
  • bA145E8.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
kinase perturbation
0.76
tissue sample
0.67
cell type or tissue
0.64
cell line
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.57   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.57   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (50)
SYCE1
Tbio
Novelty:  0.05038876
p_int:  0.999999973
p_ni:  2.2e-8
p_wrong:  5e-9
Data Source:  BioPlex
CCDC40
Tbio
Novelty:  0.06726469
p_int:  0.999999959
p_ni:  1.9e-8
p_wrong:  2.2e-8
Score:  0.188
Data Source:  BioPlex,STRINGDB
NDEL1
Tbio
Novelty:  0.01241819
p_int:  0.999999549
p_ni:  4.5e-7
p_wrong:  1e-9
Score:  0.287
Data Source:  BioPlex,STRINGDB
FAM9B
Tdark
Novelty:  0.39508009
p_int:  0.999999423
p_ni:  5.76e-7
p_wrong:  1e-9
Data Source:  BioPlex
PRKAR1A
Tbio
Family:  Enzyme
Novelty:  0.00311432
p_int:  0.999962046
p_ni:  0.000037945
p_wrong:  1e-8
Score:  0.548
Data Source:  BioPlex,STRINGDB
RALBP1
Tbio
Novelty:  0.01525176
p_int:  0.999766889
p_ni:  0.000121622
p_wrong:  0.000111489
Score:  0.186
Data Source:  BioPlex,STRINGDB
SRP72
Tbio
Novelty:  0.03264445
Score:  0.657
Data Source:  STRINGDB
SMC3
Tbio
Novelty:  0.00474377
Score:  0.654
Data Source:  STRINGDB
MASTL
Tbio
Family:  Kinase
Novelty:  0.01266037
Score:  0.642
Data Source:  STRINGDB
SMC1B
Tbio
Novelty:  0.0369537
Score:  0.634
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
1
2
73.7
body mass index
1
1
1
54.4
platelet count
1
1
1
17.1
smoking initiation
1
1
1
4.1
1
1
0
1.1
0.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
73.7
body mass index
1
54.4
platelet count
1
17.1
smoking initiation
1
4.1
0
1.1
0.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ankyrin repeat domain 26
707795
Mouse
MGI:1917887
232339
Rat
RGD:1310736
312667
Cow
ankyrin repeat domain 26
533620
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ankyrin repeat domain 26
Mouse
Rat
Cow
ankyrin repeat domain 26
Publication Statistics
PubMed Score 53.57
PubMed score by year
PubTator Score 40.65
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title