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Tdark
ANKRD13D
Ankyrin repeat domain-containing protein 13D

Protein Summary
Description
Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. The protein encoded by this gene is a member of the ankyrin repeat domain (ANKRD) 13 family, which currently consists of four proteins containing ubiquitin-interacting motifs. These proteins are integral membrane proteins that bind specifically to Lys-63-linked ubiquitin chains on membrane-bound proteins, targeting those proteins for rapid internalization. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308440
  • ENSP00000310874
  • ENSG00000172932
  • ENST00000447274
  • ENSP00000402616
  • ENST00000511455
  • ENSP00000427130
  • ENST00000514166
  • ENSP00000444404
  • ENST00000515828
  • ENSP00000443977
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.72
cell line
0.69
transcription factor binding site profile
0.65
tissue sample
0.63
transcription factor
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.59   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 50   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.59   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 50   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
LDLRAD4
Tbio
Novelty:  0.04881486
p_int:  0.999996309
p_ni:  0.000003691
Data Source:  BioPlex
FAM153B
Tdark
Novelty:  4.34922003
p_int:  0.999995621
p_ni:  0.000004379
Score:  0.169
Data Source:  BioPlex,STRINGDB
ATP6V1D
Tbio
Family:  Enzyme
Novelty:  0.02298626
p_int:  0.999970202
p_ni:  0.000029798
Data Source:  BioPlex
UBTD1
Tdark
Novelty:  0.50393104
p_int:  0.999944203
p_ni:  0.00005505
p_wrong:  7.47e-7
Data Source:  BioPlex
RALA
Tbio
Family:  Enzyme
Novelty:  0.00257914
p_int:  0.999898585
p_ni:  0.000101414
p_wrong:  1e-9
Data Source:  BioPlex
PI4K2A
Tbio
Family:  Kinase
Novelty:  0.03506675
p_int:  0.999849578
p_ni:  0.000150313
p_wrong:  1.09e-7
Data Source:  BioPlex
FAM189B
Tbio
Novelty:  0.21064304
p_int:  0.999845877
p_ni:  0.000154123
Score:  0.539
Data Source:  BioPlex,STRINGDB
ERGIC3
Tbio
Novelty:  0.11095443
p_int:  0.999811491
p_ni:  0.000188509
Data Source:  BioPlex
FAM189A2
Tdark
Novelty:  0.41335428
p_int:  0.999567398
p_ni:  0.000432601
p_wrong:  1e-9
Score:  0.167
Data Source:  BioPlex,STRINGDB
CSNK1G3
Tchem
Family:  Kinase
Novelty:  0.07584067
p_int:  0.999371892
p_ni:  0.000624073
p_wrong:  0.000004035
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
2
2
3
92.7
mean corpuscular volume
1
1
1
83.8
BMI-adjusted hip circumference
1
1
1
82.5
waist circumference
1
1
1
71.5
red blood cell distribution width
1
1
1
60.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
3
92.7
mean corpuscular volume
1
83.8
BMI-adjusted hip circumference
1
82.5
waist circumference
1
71.5
red blood cell distribution width
1
60.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat domain 13D
VGNC:3220
451364
Macaque
ankyrin repeat domain 13D
721749
Mouse
MGI:1915673
68423
Rat
RGD:1309156
361699
Dog
ankyrin repeat domain 13D
VGNC:37887
483700
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat domain 13D
Macaque
ankyrin repeat domain 13D
Mouse
Rat
Dog
ankyrin repeat domain 13D
Publication Statistics
PubMed Score 0.59
PubMed score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title