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Tbio
ANKRD12
Ankyrin repeat domain-containing protein 12

Protein Summary
Description
May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. This gene encodes a member of the ankyrin repeats-containing cofactor family. These proteins may inhibit the transcriptional activity of nuclear receptors through the recruitment of histone deacetylases. The encoded protein interacts with p160 coactivators and also represses transcription mediated by the coactivator alteration/deficiency in activation 3 (ADA3). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262126
  • ENSP00000262126
  • ENSG00000101745
  • ENST00000400020
  • ENSP00000382897

Symbol
  • ANCO2
  • KIAA0874
  • ANCO1
  • GAC-1
  • ANCO-2
  • Nbla00144
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.95
cell type or tissue
0.71
transcription factor binding site profile
0.71
histone modification site profile
0.7
transcription factor
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.78   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 56   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.78   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 56   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (46)
SGPL1
Tchem
Family:  Enzyme
Novelty:  0.00272574
p_int:  0.999938737
p_ni:  0.000061263
Score:  0.187
Data Source:  BioPlex,STRINGDB
PHYHIP
Tdark
Family:  Enzyme
Novelty:  0.25773185
p_int:  0.998332033
p_ni:  0.001579811
p_wrong:  0.000088156
Score:  0.199
Data Source:  BioPlex,STRINGDB
ULBP2
Tbio
Novelty:  0.01604318
p_int:  0.958984999
p_ni:  0.041014983
p_wrong:  1.8e-8
Score:  0.28
Data Source:  BioPlex,STRINGDB
SLIT2
Tbio
Novelty:  0.00710401
p_int:  0.954530617
p_ni:  0.045469383
Score:  0.28
Data Source:  BioPlex,STRINGDB
RSF1
Tbio
Family:  Epigenetic
Novelty:  0.0155058
Score:  0.839
Data Source:  STRINGDB
LRRC30
Tdark
Novelty:  2.30668103
Score:  0.781
Data Source:  STRINGDB
NIPBL
Tbio
Novelty:  0.00462654
Score:  0.708
Data Source:  STRINGDB
ZBTB14
Tbio
Family:  TF
Novelty:  0.0245914
Score:  0.684
Data Source:  STRINGDB
ARHGAP28
Tdark
Family:  Enzyme
Novelty:  0.33612416
Score:  0.665
Data Source:  STRINGDB
Q8N726
Tbio
Novelty:  0.00014147
Score:  0.663
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
1
1
66.4
mean corpuscular hemoglobin concentration
1
1
1
49.5
heel bone mineral density
1
1
1
46.5
red blood cell distribution width
1
1
1
46
self reported educational attainment
1
1
1
44.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
66.4
mean corpuscular hemoglobin concentration
1
49.5
heel bone mineral density
1
46.5
red blood cell distribution width
1
46
self reported educational attainment
1
44.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat domain 12
VGNC:5140
468478
Mouse
MGI:1914357
106585
Rat
RGD:1310118
316775
Dog
ankyrin repeat domain 12
VGNC:37883
480205
Horse
ankyrin repeat domain 12
VGNC:15320
100049929
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat domain 12
Mouse
Rat
Dog
ankyrin repeat domain 12
Horse
ankyrin repeat domain 12
Publication Statistics
PubMed Score 11.78
PubMed score by year
PubTator Score 10.04
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title