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Tbio
ANKRD11
Ankyrin repeat domain-containing protein 11

Protein Summary
Description
Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). This locus encodes an ankryin repeat domain-containing protein. The encoded protein inhibits ligand-dependent activation of transcription. Mutations in this gene have been associated with KBG syndrome, which is characterized by macrodontia, distinctive craniofacial features, short stature, skeletal anomalies, global developmental delay, seizures and intellectual disability. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 2 and X. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301030
  • ENSP00000301030
  • ENSG00000167522
  • ENST00000378330
  • ENSP00000367581
  • ENST00000642600
  • ENSP00000495226

Symbol
  • ANCO1
  • T13
  • LZ16
  • ANCO1
  • ANCO-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
transcription factor binding site profile
0.95
ligand (protein) perturbation
0.83
virus perturbation
0.79
disease perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.1   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 125   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.1   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (25)
GPS2
Tbio
Novelty:  0.00986158
p_int:  1
Score:  0.372
Data Source:  BioPlex,STRINGDB
CD6
Tbio
Novelty:  0.00309541
Score:  0.7
Data Source:  STRINGDB
KMT2D
Tbio
Family:  Epigenetic
Novelty:  0.00380525
Score:  0.693
Data Source:  STRINGDB
ZNF778
Tdark
Family:  TF
Novelty:  0.34526773
Score:  0.676
Data Source:  STRINGDB
NCOA2
Tbio
Novelty:  0.00510052
Score:  0.669
Data Source:  STRINGDB
HDAC5
Tclin
Family:  Epigenetic
Novelty:  0.00484422
Score:  0.668
Data Source:  STRINGDB
NCOA3
Tchem
Family:  Epigenetic
Novelty:  0.00193529
Score:  0.668
Data Source:  STRINGDB
RSF1
Tbio
Family:  Epigenetic
Novelty:  0.0155058
Score:  0.642
Data Source:  STRINGDB
NCOA1
Tchem
Family:  Epigenetic
Novelty:  0.00344663
Score:  0.628
Data Source:  STRINGDB
HDAC4
Tclin
Family:  Epigenetic
Novelty:  0.00217749
Score:  0.627
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
1
4
4
98.9
1
2
0
1.3
88.7
1
2
0
1.3
85.8
non-melanoma skin carcinoma
1
2
0
1.3
81.4
smoking status measurement
2
1
2
59.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
4
98.9
0
1.3
88.7
0
1.3
85.8
non-melanoma skin carcinoma
0
1.3
81.4
smoking status measurement
2
59.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat domain 11
VGNC:13660
468078
Macaque
ankyrin repeat domain 11
698722
Mouse
MGI:1924337
77087
Rat
RGD:1306679
365023
Dog
ankyrin repeat domain 11
VGNC:37882
489658
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat domain 11
Macaque
ankyrin repeat domain 11
Mouse
Rat
Dog
ankyrin repeat domain 11
Publication Statistics
PubMed Score 108.10
PubMed score by year
PubTator Score 147.77
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title