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Tbio
ANKRA2
Ankyrin repeat family A protein 2

Protein Summary
Description
May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5 (PubMed:25752541). May also regulate LRP2/megalin (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296785
  • ENSP00000296785
  • ENSG00000164331

Symbol
  • ANKRA
  • ANKRA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
histone modification site profile
0.92
transcription factor perturbation
0.8
transcription factor binding site profile
0.66
tissue sample
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.7   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.7   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (47)
RFX5
Tbio
Family:  TF
Novelty:  0.02002111
p_int:  0.981557841
p_wrong:  0.018442159
Score:  0.9
Data Source:  BioPlex,STRINGDB
HDAC4
Tclin
Family:  Epigenetic
Novelty:  0.00217749
Score:  0.998
Data Source:  STRINGDB
HDAC5
Tclin
Family:  Epigenetic
Novelty:  0.00484422
Score:  0.992
Data Source:  STRINGDB
RFX7
Tdark
Family:  TF
Novelty:  0.15609316
Score:  0.976
Data Source:  STRINGDB
CCDC8
Tbio
Novelty:  0.07526278
Score:  0.974
Data Source:  STRINGDB
PRR19
Tdark
Novelty:  0.52254246
Score:  0.908
Data Source:  STRINGDB
LRP2
Tbio
Novelty:  0.00143258
Score:  0.884
Data Source:  STRINGDB
HDAC9
Tclin
Family:  Epigenetic
Novelty:  0.00382278
Score:  0.858
Data Source:  STRINGDB
HDAC7
Tclin
Family:  Epigenetic
Novelty:  0.00600484
Score:  0.772
Data Source:  STRINGDB
HDAC10
Tclin
Family:  Epigenetic
Novelty:  0.00976829
Score:  0.731
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
2
4
73.9
reticulocyte count
2
1
2
40.8
high density lipoprotein cholesterol measurement
1
1
1
36.6
reticulocyte measurement
2
1
2
32.3
apolipoprotein A 1 measurement
2
2
2
20.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
73.9
reticulocyte count
2
40.8
high density lipoprotein cholesterol measurement
1
36.6
reticulocyte measurement
2
32.3
apolipoprotein A 1 measurement
2
20.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat family A member 2
VGNC:6377
461810
Macaque
ankyrin repeat family A member 2
703691
Mouse
MGI:1915808
68558
Rat
RGD:1303108
294679
Dog
ankyrin repeat family A member 2
VGNC:37879
478097
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat family A member 2
Macaque
ankyrin repeat family A member 2
Mouse
Rat
Dog
ankyrin repeat family A member 2
Publication Statistics
PubMed Score 6.70
PubMed score by year
PubTator Score 3.38
PubTator score by year
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Related Publications
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PMID
Year
Title