Tbio ANKRA2 Ankyrin repeat family A protein 2

Protein Summary

Description

May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5 (PubMed:25752541). May also regulate LRP2/megalin (By similarity).

Uniprot Accession IDs

• Q9H9E1

Gene Name

• ANKRA2

Ensembl ID

• ENST00000296785
• ENSP00000296785
• ENSG00000164331

Symbol

• ANKRA
• ANKRA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.99
histone modification site profile	0.92
transcription factor perturbation	0.8
transcription factor binding site profile	0.66
tissue sample	0.64

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Ankyrin Repeat Family A Protein 2

DTO Classes

Protein / Transcription Factor / Ankyrin Repeat Family A Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.7   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 164   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.7   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0