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Tbio
ANK3
Ankyrin-3

Protein Summary
Description
In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Isoform 5: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000280772
  • ENSP00000280772
  • ENSG00000151150
  • ENST00000355288
  • ENSP00000347436
  • ENST00000373827
  • ENSP00000362933
  • ENST00000503366
  • ENSP00000425236

Symbol
  • MRT37
  • ANKYRIN-G
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
biological process
0.97
trait
0.97
microRNA
0.95
disease perturbation
0.93


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 236.05   (req: < 5)
Gene RIFs: 71   (req: <= 3)
Antibodies: 245   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 236.05   (req: >= 5)
Gene RIFs: 71   (req: > 3)
Antibodies: 245   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (219)
RAPGEF5
Tbio
Novelty:  0.02449802
p_int:  0.999999985
p_ni:  1.5e-8
Score:  0.218
Data Source:  BioPlex,STRINGDB
PALM2
Tbio
Novelty:  0.03469098
p_int:  0.999999789
p_ni:  2.11e-7
Score:  0.226
Data Source:  BioPlex,STRINGDB
BTF3
Tbio
Novelty:  0.01198537
p_int:  0.99999898
p_ni:  0.00000102
Data Source:  BioPlex
CHL1
Tbio
Novelty:  0.00055237
p_int:  0.99999857
p_ni:  0.00000143
Score:  0.612
Data Source:  BioPlex,STRINGDB
PPP1R12B
Tbio
Family:  Enzyme
Novelty:  0.0424259
p_int:  0.999997804
p_ni:  0.000002196
Data Source:  BioPlex
MAPK8IP1
Tbio
Family:  Enzyme
Novelty:  0.00284875
p_int:  0.999997159
p_ni:  0.000002841
Score:  0.223
Data Source:  BioPlex,STRINGDB
FEZ1
Tbio
Novelty:  0.02695814
p_int:  0.999993726
p_ni:  0.000006274
Score:  0.203
Data Source:  BioPlex,STRINGDB
HIF1AN
Tbio
Novelty:  0.00861018
p_int:  0.999944311
p_ni:  0.000055689
Score:  0.239
Data Source:  BioPlex,STRINGDB
UXS1
Tbio
Family:  Enzyme
Novelty:  0.04671281
p_int:  0.999783239
p_ni:  0.000216761
Score:  0.156
Data Source:  BioPlex,STRINGDB
PWP1
Tbio
Novelty:  0.07040539
p_int:  0.99906317
p_ni:  0.00093683
Score:  0.255
Data Source:  BioPlex,STRINGDB
Pathways (14)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Axon guidance
Reactome
COPI-mediated anterograde transport
Reactome
Developmental Biology
Reactome
ER to Golgi Anterograde Transport
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Axon guidance
COPI-mediated anterograde transport
Developmental Biology
ER to Golgi Anterograde Transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (56)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
5
0
1.2
65.7
diastolic blood pressure
1
1
1
50.6
biological sex
1
1
1
48.5
body height
1
1
1
47.7
waist-hip ratio
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
65.7
diastolic blood pressure
1
50.6
biological sex
1
48.5
body height
1
47.7
waist-hip ratio
1
39.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ankyrin 3
VGNC:14318
450478
Macaque
ankyrin 3
699518
Mouse
MGI:88026
11735
Dog
ankyrin 3
VGNC:37867
479215
Cow
ankyrin 3, node of Ranvier (ankyrin G)
511203
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ankyrin 3
Macaque
ankyrin 3
Mouse
Dog
ankyrin 3
Cow
ankyrin 3, node of Ranvier (ankyrin G)
Publication Statistics
PubMed Score 236.05
PubMed score by year
PubTator Score 125.96
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title