Protein Summary
In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Isoform 5: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of ...more
- ENST00000280772
- ENSP00000280772
- ENSG00000151150
- ENST00000355288
- ENSP00000347436
- ENST00000373827
- ENSP00000362933
- ENST00000503366
- ENSP00000425236
- MRT37
- ANKYRIN-G
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor perturbation | 1 | ||
biological process | 0.97 | ||
trait | 0.97 | ||
microRNA | 0.95 | ||
disease perturbation | 0.93 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 236.05 (req: < 5)
Gene RIFs: 71 (req: <= 3)
Antibodies: 245 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 236.05 (req: >= 5)
Gene RIFs: 71 (req: > 3)
Antibodies: 245 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 33
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (219)
RAPGEF5
Novelty: 0.02449802
p_int: 0.999999985
p_ni: 1.5e-8
Score: 0.218
Data Source: BioPlex,STRINGDB
PALM2
Novelty: 0.03469098
p_int: 0.999999789
p_ni: 2.11e-7
Score: 0.226
Data Source: BioPlex,STRINGDB
CHL1
Novelty: 0.00055237
p_int: 0.99999857
p_ni: 0.00000143
Score: 0.612
Data Source: BioPlex,STRINGDB
PPP1R12B
Family: Enzyme
Novelty: 0.0424259
p_int: 0.999997804
p_ni: 0.000002196
Data Source: BioPlex
MAPK8IP1
Family: Enzyme
Novelty: 0.00284875
p_int: 0.999997159
p_ni: 0.000002841
Score: 0.223
Data Source: BioPlex,STRINGDB
FEZ1
Novelty: 0.02695814
p_int: 0.999993726
p_ni: 0.000006274
Score: 0.203
Data Source: BioPlex,STRINGDB
HIF1AN
Novelty: 0.00861018
p_int: 0.999944311
p_ni: 0.000055689
Score: 0.239
Data Source: BioPlex,STRINGDB
UXS1
Family: Enzyme
Novelty: 0.04671281
p_int: 0.999783239
p_ni: 0.000216761
Score: 0.156
Data Source: BioPlex,STRINGDB
PWP1
Novelty: 0.07040539
p_int: 0.99906317
p_ni: 0.00093683
Score: 0.255
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (2)
Upstream (2)
1 – 2 of 2
Pathways (14)
Reactome (12)
KEGG (1)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Asparagine N-linked glycosylation | ||||
Reactome | Axon guidance | ||||
Reactome | COPI-mediated anterograde transport | ||||
Reactome | Developmental Biology | ||||
Reactome | ER to Golgi Anterograde Transport | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Asparagine N-linked glycosylation | ||||
Axon guidance | ||||
COPI-mediated anterograde transport | ||||
Developmental Biology | ||||
ER to Golgi Anterograde Transport | ||||
Viral Interactions (0)
Gene Ontology Terms (56)
Functions (6)
Components (23)
Processes (27)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Mutant Phenotype (IMP) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (17)
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
5 | 5 | 0 | 1.2 | 65.7 | |||||
diastolic blood pressure | 1 | 1 | 1 | 50.6 | |||||
biological sex | 1 | 1 | 1 | 48.5 | |||||
body height | 1 | 1 | 1 | 47.7 | |||||
waist-hip ratio | 1 | 1 | 1 | 39.6 | |||||
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 1.2 | 65.7 | |||||
diastolic blood pressure | 1 | 50.6 | |||||
biological sex | 1 | 48.5 | |||||
body height | 1 | 47.7 | |||||
waist-hip ratio | 1 | 39.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | ankyrin 3 | VGNC:14318 | 450478 | |||||
Macaque | ankyrin 3 | 699518 | ||||||
Mouse | MGI:88026 | 11735 | ||||||
Dog | ankyrin 3 | VGNC:37867 | 479215 | |||||
Cow | ankyrin 3, node of Ranvier (ankyrin G) | 511203 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | ankyrin 3 | |||||
Macaque | ankyrin 3 | |||||
Mouse | ||||||
Dog | ankyrin 3 | |||||
Cow | ankyrin 3, node of Ranvier (ankyrin G) | |||||
Publication Statistics
PubMed Score 236.05
PubMed score by year
PubTator Score 125.96
PubTator score by year
Related Publications
Text Mined References (98)
GeneRif Annotations (71)
Items per page:
0 of 0
PMID | Year | Title |
---|