You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ANK3
Ankyrin-3

Protein Summary
Description
In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Isoform 5: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000280772
  • ENSP00000280772
  • ENSG00000151150
  • ENST00000355288
  • ENSP00000347436
  • ENST00000373827
  • ENSP00000362933
  • ENST00000503366
  • ENSP00000425236

Symbol
  • MRT37
  • ANKYRIN-G
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
biological process
0.97
trait
0.97
microRNA
0.95
disease perturbation
0.93


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 241.99   (req: < 5)
Gene RIFs: 71   (req: <= 3)
Antibodies: 245   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 241.99   (req: >= 5)
Gene RIFs: 71   (req: > 3)
Antibodies: 245   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0