You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ANK2
Ankyrin-2

Protein Summary
Description
Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Ass ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357077
  • ENSP00000349588
  • ENSG00000145362
  • ENST00000394537
  • ENSP00000378044
  • ENST00000506722
  • ENSP00000421067
  • ENST00000510275
  • ENSP00000421023

Symbol
  • ANKB
  • LQT4
  • ANK-2
  • brank-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
biological process
0.98
hub protein
0.94
kinase
0.9
cellular component
0.89


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 231.66   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 327   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 231.66   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 327   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 50
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0