Protein Summary
Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Ass ...more
- ENST00000357077
- ENSP00000349588
- ENSG00000145362
- ENST00000394537
- ENSP00000378044
- ENST00000506722
- ENSP00000421067
- ENST00000510275
- ENSP00000421023
- ANKB
- LQT4
- ANK-2
- brank-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
trait | 1 | ||
biological process | 0.98 | ||
hub protein | 0.94 | ||
kinase | 0.9 | ||
cellular component | 0.89 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 211.34 (req: < 5)
Gene RIFs: 39 (req: <= 3)
Antibodies: 327 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 211.34 (req: >= 5)
Gene RIFs: 39 (req: > 3)
Antibodies: 327 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 50
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (257)
PALM2
Novelty: 0.03469098
p_int: 0.999996185
p_ni: 0.000003815
Score: 0.238
Data Source: BioPlex,STRINGDB
RAPGEF5
Novelty: 0.02449802
p_int: 0.999993677
p_ni: 0.000006321
p_wrong: 2e-9
Score: 0.269
Data Source: BioPlex,STRINGDB
CHL1
Novelty: 0.00055237
p_int: 0.999971248
p_ni: 0.000028752
Score: 0.64
Data Source: BioPlex,STRINGDB
PPP1R12B
Family: Enzyme
Novelty: 0.0424259
p_int: 0.999149744
p_ni: 0.000850018
p_wrong: 2.38e-7
Data Source: BioPlex
MAPK8IP1
Family: Enzyme
Novelty: 0.00284875
p_int: 0.992460769
p_ni: 0.007539231
Score: 0.284
Data Source: BioPlex,STRINGDB
HIF1AN
Novelty: 0.00861018
p_int: 0.964420245
p_ni: 0.035579754
Score: 0.235
Data Source: BioPlex,STRINGDB
DNAAF2
Novelty: 0.01254416
p_int: 0.951917758
p_ni: 0.048082242
Score: 0.161
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (2)
Upstream (2)
1 – 2 of 2
Pathways (13)
Reactome (12)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Asparagine N-linked glycosylation | ||||
Reactome | Axon guidance | ||||
Reactome | COPI-mediated anterograde transport | ||||
Reactome | Developmental Biology | ||||
Reactome | ER to Golgi Anterograde Transport | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Asparagine N-linked glycosylation | ||||
Axon guidance | ||||
COPI-mediated anterograde transport | ||||
Developmental Biology | ||||
ER to Golgi Anterograde Transport | ||||
Viral Interactions (0)
Gene Ontology Terms (70)
Functions (8)
Components (20)
Processes (42)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
testosterone measurement | 2 | 2 | 2 | 83.9 | |||||
nitric oxide exhalation measurement | 1 | 1 | 1 | 56.8 | |||||
1 | 1 | 0 | 1.1 | 46.9 | |||||
1 | 1 | 0 | 1.2 | 44.2 | |||||
small vessel stroke | 1 | 1 | 0 | 1.3 | 24.5 | ||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
testosterone measurement | 2 | 83.9 | |||||
nitric oxide exhalation measurement | 1 | 56.8 | |||||
0 | 1.1 | 46.9 | |||||
0 | 1.2 | 44.2 | |||||
small vessel stroke | 0 | 1.3 | 24.5 | ||||
Find similar targets by:
IDG Resources
Orthologs (3)
1 – 3 of 3
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | ankyrin 2 | 702180 | ||||||
Mouse | MGI:88025 | 109676 | ||||||
Rat | RGD:620156 | 362036 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | ankyrin 2 | |||||
Mouse | ||||||
Rat | ||||||
Publication Statistics
PubMed Score 211.34
PubMed score by year
PubTator Score 84.95
PubTator score by year
Related Publications
Text Mined References (76)
GeneRif Annotations (39)
Items per page:
0 of 0
PMID | Year | Title |
---|