Protein Summary
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000325203
- ENSP00000314897
- ENSG00000091879
- ENST00000338312
- ENSP00000343517
- ENST00000629816
- ENSP00000486858
- ANG2
- AGPT2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 1 | ||
disease | 0.83 | ||
biological process | 0.8 | ||
virus perturbation | 0.79 | ||
microRNA | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1066.17 (req: < 5)
Gene RIFs: 382 (req: <= 3)
Antibodies: 548 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1066.17 (req: >= 5)
Gene RIFs: 382 (req: > 3)
Antibodies: 548 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 23
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (122)
ZZEF1
Novelty: 0.33216648
p_int: 0.99901623
p_ni: 0.00098377
Score: 0.161
Data Source: BioPlex,STRINGDB
FBXO28
Novelty: 0.10548865
p_int: 0.996854511
p_ni: 0.00314548
p_wrong: 9e-9
Score: 0.165
Data Source: BioPlex,STRINGDB
HECTD3
Family: Enzyme
Novelty: 2.20874654
p_int: 0.991707186
p_ni: 0.008292814
Score: 0.189
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (18)
Downstream (18)
1 – 5 of 18
Pathways (182)
Reactome (3)
KEGG (6)
PathwayCommons (2)
WikiPathways (171)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell surface interactions at the vascular wall | ||||
Reactome | Hemostasis | ||||
Reactome | Tie2 Signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell surface interactions at the vascular wall | ||||
Hemostasis | ||||
Tie2 Signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (28)
Functions (3)
Components (5)
Processes (20)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
carotid artery intima media thickness | 2 | 3 | 4 | 75.7 | |||||
heel bone mineral density | 2 | 2 | 3 | 71.4 | |||||
intraocular pressure measurement | 4 | 1 | 4 | 64.4 | |||||
diastolic blood pressure | 1 | 1 | 1 | 59.9 | |||||
birth weight | 1 | 1 | 1 | 52 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
carotid artery intima media thickness | 4 | 75.7 | |||||
heel bone mineral density | 3 | 71.4 | |||||
intraocular pressure measurement | 4 | 64.4 | |||||
diastolic blood pressure | 1 | 59.9 | |||||
birth weight | 1 | 52 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | angiopoietin 2 | VGNC:921 | 742508 | |||||
Macaque | angiopoietin 2 | 716811 | ||||||
Mouse | MGI:1202890 | 11601 | ||||||
Rat | RGD:621861 | 89805 | ||||||
Dog | angiopoietin 2 | VGNC:37855 | 607616 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | angiopoietin 2 | |||||
Macaque | angiopoietin 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | angiopoietin 2 | |||||
Publication Statistics
PubMed Score 1066.17
PubMed score by year
PubTator Score 838.54
PubTator score by year
Related Publications
Text Mined References (406)
GeneRif Annotations (382)
Items per page:
0 of 0
PMID | Year | Title |
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