Tbio ANAPC7 Anaphase-promoting complex subunit 7

Protein Summary

Description

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. This gene encodes a tetratricopeptide repeat containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

Uniprot Accession IDs

• Q9UJX3
• Q96AC4
• Q96GF4
• Q9BU24
• Q9NT16
• APC7

Gene Name

• ANAPC7

Ensembl ID

• ENST00000450008
• ENSP00000402314
• ENSG00000196510
• ENST00000455511
• ENSP00000394394

Symbol

• APC7
• APC7

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.94
interacting protein	0.91
histone modification site profile	0.9
kinase perturbation	0.76
virus perturbation	0.76

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.83   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 87   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.83   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0