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Tbio
ANAPC5
Anaphase-promoting complex subunit 5

Protein Summary
Description
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site- ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261819
  • ENSP00000261819
  • ENSG00000089053
  • ENST00000441917
  • ENSP00000415061

Symbol
  • APC5
  • APC5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
disease perturbation
1
kinase perturbation
1
transcription factor perturbation
1
virus perturbation
0.95


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.28   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 329   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.28   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 329   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (413)
ANAPC2
Tbio
Family:  Enzyme
Novelty:  0.19812984
p_int:  0.999999992
p_ni:  8e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
ANAPC4
Tbio
Family:  Enzyme
Novelty:  0.28937094
p_int:  0.999999985
p_ni:  1.5e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
CDC27
Tbio
Novelty:  0.00589846
p_int:  0.999999549
p_ni:  4.51e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
NEK2
Tchem
Family:  Kinase
Novelty:  0.0059613
p_int:  0.999998968
p_ni:  0.000001011
p_wrong:  2.1e-8
Score:  0.927
Data Source:  BioPlex,STRINGDB
ANAPC1
Tbio
Family:  Enzyme
Novelty:  0.0521845
p_int:  0.999997816
p_ni:  0.000002184
Score:  0.999
Data Source:  BioPlex,STRINGDB
CDC23
Tbio
Novelty:  0.0168525
p_int:  0.99999748
p_ni:  0.000002516
p_wrong:  4e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
FBXO5
Tbio
Novelty:  0.01571484
p_int:  0.999996927
p_ni:  8.85e-7
p_wrong:  0.000002188
Score:  0.924
Data Source:  BioPlex,STRINGDB
CDC16
Tbio
Novelty:  0.00916715
p_int:  0.999996427
p_ni:  0.000003573
Score:  0.999
Data Source:  BioPlex,STRINGDB
CDC26
Tbio
Family:  Enzyme
Novelty:  0.07456358
p_int:  0.999995545
p_ni:  0.000004171
p_wrong:  2.84e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
ANAPC13
Tbio
Family:  Enzyme
Novelty:  0.06125489
p_int:  0.999994955
p_ni:  0.000005045
Score:  0.999
Data Source:  BioPlex,STRINGDB
Pathways (63)
APC-Cdc20 mediated degradation of Nek2A (R-HSA-179409)

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Find Similar Targets
Items per page:
1 – 5 of 37
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
APC-Cdc20 mediated degradation of Nek2A
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Cyclin B
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
APC-Cdc20 mediated degradation of Nek2A
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Cyclin B
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
2
10
10
96.2
serum gamma-glutamyl transferase measurement
2
6
6
93.2
neutrophil percentage of leukocytes
1
1
1
52.7
body mass index
2
1
2
52
lymphocyte percentage of leukocytes
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
10
96.2
serum gamma-glutamyl transferase measurement
6
93.2
neutrophil percentage of leukocytes
1
52.7
body mass index
2
52
lymphocyte percentage of leukocytes
1
42.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
anaphase promoting complex subunit 5
VGNC:4921
452321
Mouse
MGI:1929722
59008
Rat
RGD:1306125
288671
Dog
anaphase promoting complex subunit 5
VGNC:37851
477471
Horse
anaphase promoting complex subunit 5
VGNC:15295
100058548
Species
Name
OMA
EggNOG
Inparanoid
Chimp
anaphase promoting complex subunit 5
Mouse
Rat
Dog
anaphase promoting complex subunit 5
Horse
anaphase promoting complex subunit 5
Publication Statistics
PubMed Score 46.28
PubMed score by year
PubTator Score 17.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title