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Tbio
ANAPC11
Anaphase-promoting complex subunit 11

Protein Summary
Description
Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344877
  • ENSP00000339695
  • ENSG00000141552
  • ENST00000357385
  • ENSP00000349957
  • ENST00000392376
  • ENSP00000376181
  • ENST00000571024
  • ENSP00000461648
  • ENST00000571570
  • ENSP00000458143
  • ENST00000571874
  • ENSP00000459200
  • ENST00000572639
  • ENSP00000460678
  • ENST00000572851
  • ENSP00000458265
  • ENST00000574924
  • ENSP00000460064
  • ENST00000575195
  • ENSP00000458515
  • ENST00000577747
  • ENSP00000463567
  • ENST00000578550
  • ENSP00000464615
  • ENST00000579978
  • ENSP00000463640
  • ENST00000583839
  • ENSP00000463598

Symbol
  • APC11
  • Apc11p
  • HSPC214
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.94
virus perturbation
0.92
histone modification site profile
0.8
disease perturbation
0.74
cell type or tissue
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.14   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 324   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.14   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 324   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (413)
CDC16
Tbio
Novelty:  0.00916715
Score:  0.999
Data Source:  STRINGDB
ANAPC4
Tbio
Family:  Enzyme
Novelty:  0.28937094
Score:  0.999
Data Source:  STRINGDB
PTTG1
Tbio
Novelty:  0.00304349
Score:  0.999
Data Source:  STRINGDB
UBE2C
Tbio
Novelty:  0.00731185
Score:  0.999
Data Source:  STRINGDB
ANAPC2
Tbio
Family:  Enzyme
Novelty:  0.19812984
Score:  0.999
Data Source:  STRINGDB
FZR1
Tbio
Novelty:  0.01599606
Score:  0.999
Data Source:  STRINGDB
UBE2D2
Tbio
Novelty:  0.00603877
Score:  0.999
Data Source:  STRINGDB
UBE2S
Tbio
Novelty:  0.00363304
Score:  0.999
Data Source:  STRINGDB
CDC27
Tbio
Novelty:  0.00589846
Score:  0.999
Data Source:  STRINGDB
ANAPC10
Tbio
Family:  Enzyme
Novelty:  0.02993125
Score:  0.998
Data Source:  STRINGDB
Pathways (45)
APC-Cdc20 mediated degradation of Nek2A (R-HSA-179409)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 37
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
APC-Cdc20 mediated degradation of Nek2A
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Cyclin B
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
APC-Cdc20 mediated degradation of Nek2A
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Cyclin B
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vital capacity
1
1
1
73.2
BMI-adjusted waist-hip ratio
2
3
3
58.3
hematocrit
2
2
2
55.2
hemoglobin measurement
1
1
1
47.7
forced expiratory volume
1
1
1
46.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vital capacity
1
73.2
BMI-adjusted waist-hip ratio
3
58.3
hematocrit
2
55.2
hemoglobin measurement
1
47.7
forced expiratory volume
1
46.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
anaphase promoting complex subunit 11
VGNC:6334
454972
Macaque
anaphase promoting complex subunit 11
714909
Mouse
MGI:1913406
66156
Dog
anaphase promoting complex subunit 11
VGNC:51919
483370
Cow
anaphase promoting complex subunit 11
616275
Species
Name
OMA
EggNOG
Inparanoid
Chimp
anaphase promoting complex subunit 11
Macaque
anaphase promoting complex subunit 11
Mouse
Dog
anaphase promoting complex subunit 11
Cow
anaphase promoting complex subunit 11
Publication Statistics
PubMed Score 34.14
PubMed score by year
PubTator Score 19.61
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title