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Tbio
ANAPC11
Anaphase-promoting complex subunit 11

Protein Summary
Description
Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344877
  • ENSP00000339695
  • ENSG00000141552
  • ENST00000357385
  • ENSP00000349957
  • ENST00000392376
  • ENSP00000376181
  • ENST00000571024
  • ENSP00000461648
  • ENST00000571570
  • ENSP00000458143
  • ENST00000571874
  • ENSP00000459200
  • ENST00000572639
  • ENSP00000460678
  • ENST00000572851
  • ENSP00000458265
  • ENST00000574924
  • ENSP00000460064
  • ENST00000575195
  • ENSP00000458515
  • ENST00000577747
  • ENSP00000463567
  • ENST00000578550
  • ENSP00000464615
  • ENST00000579978
  • ENSP00000463640
  • ENST00000583839
  • ENSP00000463598

Symbol
  • APC11
  • Apc11p
  • HSPC214
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.94
virus perturbation
0.92
histone modification site profile
0.8
disease perturbation
0.74
cell type or tissue
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.07   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 324   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.07   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 324   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0