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Tdark
AMZ1
Archaemetzincin-1

Protein Summary
Description
Zinc metalloprotease. Exhibits aminopeptidase activity against neurogranin in vitro. Does not hydrolyze angiotensin-2.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312371
  • ENSP00000308149
  • ENSG00000174945
  • ENST00000407112
  • ENSP00000386020

Symbol
  • KIAA1950
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.61
cell line
0.6
cellular component
0.52
transcription factor
0.49
microRNA
0.46


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.23   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 48   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.23   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 48   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (48)
NCKAP1
Tbio
Novelty:  0.03486454
p_int:  0.999997996
p_ni:  0.000002004
Score:  0.329
Data Source:  BioPlex,STRINGDB
AIFM1
Tbio
Novelty:  0.00940088
p_int:  0.999994686
p_ni:  0.000005314
Score:  0.185
Data Source:  BioPlex,STRINGDB
WASF1
Tbio
Novelty:  0.00977488
p_int:  0.999988246
p_ni:  0.000011754
Score:  0.666
Data Source:  BioPlex,STRINGDB
NHSL1
Tdark
Novelty:  0.28557146
p_int:  0.999971321
p_ni:  0.000028679
Score:  0.827
Data Source:  BioPlex,STRINGDB
CYFIP2
Tbio
Novelty:  0.01910939
p_int:  0.999968565
p_ni:  0.000031435
Score:  0.392
Data Source:  BioPlex,STRINGDB
ABI2
Tbio
Novelty:  0.02324355
p_int:  0.999915839
p_ni:  0.00008416
Score:  0.683
Data Source:  BioPlex,STRINGDB
SUSD5
Tdark
Novelty:  1.0992718
p_int:  0.999893703
p_ni:  0.000106282
p_wrong:  1.5e-8
Score:  0.189
Data Source:  BioPlex,STRINGDB
ABI1
Tbio
Novelty:  0.00796638
p_int:  0.999825181
p_ni:  0.000174816
p_wrong:  4e-9
Score:  0.313
Data Source:  BioPlex,STRINGDB
POLD2
Tbio
Family:  Enzyme
Novelty:  0.05932998
p_int:  0.999581175
p_ni:  0.000418825
Score:  0.169
Data Source:  BioPlex,STRINGDB
BRK1
Tbio
Novelty:  0.02289534
p_int:  0.999043704
p_ni:  0.000809791
p_wrong:  0.000146505
Score:  0.571
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
8
8
12
5.9
99.4
BMI-adjusted hip circumference
4
33
39
96.6
BMI-adjusted waist circumference
4
16
19
94.9
3
2
0
1.1
92.6
body fat distribution
2
1
5
89.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
12
5.9
99.4
BMI-adjusted hip circumference
39
96.6
BMI-adjusted waist circumference
19
94.9
0
1.1
92.6
body fat distribution
5
89.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
archaelysin family metallopeptidase 1
VGNC:4257
738827
Mouse
MGI:2442258
231842
Rat
RGD:1311314
304317
Dog
archaelysin family metallopeptidase 1
VGNC:37842
489888
Horse
archaelysin family metallopeptidase 1
VGNC:15287
100059978
Species
Name
OMA
EggNOG
Inparanoid
Chimp
archaelysin family metallopeptidase 1
Mouse
Rat
Dog
archaelysin family metallopeptidase 1
Horse
archaelysin family metallopeptidase 1
Publication Statistics
PubMed Score 5.23
PubMed score by year
PubTator Score 2.87
PubTator score by year
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Related Publications
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PMID
Year
Title