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Tclin
AMY2A
Pancreatic alpha-amylase

Protein Summary
Description
This gene encodes a member of the alpha-amylase family of proteins. Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, catalyzing the first step in digestion of dietary starch and glycogen. This gene and several family members are present in a gene cluster on chromosome 1. This gene encodes an amylase isoenzyme produced by the pancreas. [provided by RefSeq, Jan 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000414303
  • ENSP00000397582
  • ENSG00000243480
  • ENST00000622339
  • ENSP00000481450

Symbol
  • PA
  • AMY2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
protein domain
0.97
drug
0.72
disease
0.52
molecular function
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 734.8   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 407   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 734.8   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 407   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (63)
AMY2B
Tbio
Family:  Enzyme
Novelty:  0.01126737
p_int:  1
Score:  0.806
Data Source:  BioPlex,STRINGDB
GYG2
Tbio
Family:  Enzyme
Novelty:  0.01520991
p_int:  0.99993328
p_ni:  0.000028788
p_wrong:  0.000037932
Score:  0.172
Data Source:  BioPlex,STRINGDB
GYS1
Tchem
Family:  Enzyme
Novelty:  0.00721964
p_int:  0.999674686
p_ni:  0.000325314
Score:  0.202
Data Source:  BioPlex,STRINGDB
TOMM7
Tbio
Novelty:  0.03885154
p_int:  0.998978246
p_ni:  0.001021753
p_wrong:  1e-9
Data Source:  BioPlex
BCL2L12
Tbio
Novelty:  0.01773637
p_int:  0.996068151
p_ni:  0.002730038
p_wrong:  0.00120181
Score:  0.68
Data Source:  BioPlex,STRINGDB
GYG1
Tbio
Family:  Enzyme
Novelty:  0.01446978
p_int:  0.983939488
p_ni:  0.016060512
Score:  0.218
Data Source:  BioPlex,STRINGDB
HSPA5
Tchem
Novelty:  0.00043424
p_int:  0.956808711
p_ni:  0.043191289
Data Source:  BioPlex
MGAM2
Tdark
Family:  Enzyme
Novelty:  0.03471933
Score:  0.98
Data Source:  STRINGDB
SI
Tchem
Family:  Enzyme
Novelty:  0.00048694
Score:  0.971
Data Source:  STRINGDB
MGAM
Tclin
Family:  Enzyme
Novelty:  0.00045865
Score:  0.971
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Digestion (R-HSA-8935690)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Digestion
Reactome
Digestion and absorption
Reactome
Digestion of dietary carbohydrate
Name
Explore in Pharos
Explore in Source
Digestion
Digestion and absorption
Digestion of dietary carbohydrate
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 734.80
PubMed score by year
PubTator Score 214.80
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title