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Tbio
AMPH
Amphiphysin

Protein Summary
Description
May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton. This gene encodes a protein associated with the cytoplasmic surface of synaptic vesicles. A subset of patients with stiff-man syndrome who were also affected by breast cancer are positive for autoantibodies against this protein. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences have not been determined. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325590
  • ENSP00000317441
  • ENSG00000078053
  • ENST00000356264
  • ENSP00000348602

Symbol
  • AMPH1
  • AMPH1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
kinase
0.87
trait
0.86
hub protein
0.82
protein domain
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 450.38   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 460   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 450.38   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 460   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (256)
BIN1
Tbio
Novelty:  0.00312612
p_int:  0.999999998
p_ni:  2e-9
Score:  0.97
Data Source:  BioPlex,Reactome,STRINGDB
BIN2
Tbio
Novelty:  0.00952157
p_int:  0.999999853
p_ni:  1.47e-7
Score:  0.818
Data Source:  BioPlex,STRINGDB
AP2A2
Tbio
Novelty:  0.08851191
p_int:  0.999965988
p_ni:  0.000034012
Score:  0.972
Data Source:  BioPlex,STRINGDB
AP2A1
Tbio
Novelty:  0.08554974
p_int:  0.999910073
p_ni:  0.000089927
Score:  0.987
Data Source:  BioPlex,STRINGDB
AP1B1
Tbio
Novelty:  0.03370208
p_int:  0.999742773
p_ni:  0.000257227
Score:  0.641
Data Source:  BioPlex,STRINGDB
AP2M1
Tbio
Novelty:  0.00769368
p_int:  0.999493217
p_ni:  0.000506783
Score:  0.958
Data Source:  BioPlex,STRINGDB
AP2S1
Tbio
Novelty:  0.01931502
p_int:  0.993758411
p_ni:  0.006241581
p_wrong:  9e-9
Score:  0.979
Data Source:  BioPlex,STRINGDB
AP2B1
Tbio
Novelty:  0.00921093
p_int:  0.993414653
p_ni:  0.006585347
Score:  0.986
Data Source:  BioPlex,STRINGDB
AAGAB
Tbio
Novelty:  0.0479209
p_int:  0.991253355
p_ni:  0.008744089
p_wrong:  0.000002556
Score:  0.821
Data Source:  BioPlex,STRINGDB
CLIP4
Tdark
Novelty:  0.95653865
p_int:  0.974256498
p_ni:  0.025743502
Score:  0.481
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Clathrin-mediated endocytosis (R-HSA-8856828)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Clathrin-mediated endocytosis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Clathrin-mediated endocytosis
Membrane Trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
major depressive disorder
1
1
1
3.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
major depressive disorder
1
3.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
amphiphysin
VGNC:4256
463363
Macaque
amphiphysin
704559
Mouse
MGI:103574
218038
Rat
RGD:620274
60668
Dog
amphiphysin
VGNC:37840
475877
Species
Name
OMA
EggNOG
Inparanoid
Chimp
amphiphysin
Macaque
amphiphysin
Mouse
Rat
Dog
amphiphysin
Publication Statistics
PubMed Score 450.38
PubMed score by year
PubTator Score 58.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title