AMOTL2
Angiomotin-like protein 2
Protein Summary
Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC. Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motin protein family. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
- ENST00000249883
- ENSP00000249883
- ENSG00000114019
- ENST00000422605
- ENSP00000409999
- ENST00000513145
- ENSP00000425475
- ENST00000514516
- ENSP00000424765
- KIAA0989
- LCCP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.9 | ||
kinase perturbation | 0.88 | ||
PubMedID | 0.86 | ||
transcription factor binding site profile | 0.8 | ||
disease perturbation | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 25.86 (req: < 5)
Gene RIFs: 11 (req: <= 3)
Antibodies: 93 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 25.86 (req: >= 5)
Gene RIFs: 11 (req: > 3)
Antibodies: 93 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (51)
MPP5
Novelty: 0.01707773
p_int: 0.999999982
p_ni: 8e-9
p_wrong: 9e-9
Score: 0.605
Data Source: BioPlex,STRINGDB
NUP62
Novelty: 0.01432724
p_int: 0.999913559
p_ni: 0.000085005
p_wrong: 0.000001436
Data Source: BioPlex
HTATIP2
Family: Enzyme
Novelty: 0.01940704
p_int: 0.999819993
p_ni: 0.000179956
p_wrong: 5.1e-8
Score: 0.54
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (3)
Reactome (2)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Signal Transduction | ||||
Reactome | Signaling by Hippo | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Signal Transduction | ||||
Signaling by Hippo | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (1)
Components (5)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
reticulocyte measurement | 2 | 1 | 2 | 47.7 | |||||
Myopia | 1 | 1 | 0 | 6.1 | 35 | ||||
refractive error measurement | 1 | 1 | 0 | 6.1 | 35 | ||||
age at onset | 1 | 1 | 0 | 6.1 | 35 | ||||
reticulocyte count | 1 | 1 | 1 | 33.1 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
reticulocyte measurement | 2 | 47.7 | |||||
Myopia | 0 | 6.1 | 35 | ||||
refractive error measurement | 0 | 6.1 | 35 | ||||
age at onset | 0 | 6.1 | 35 | ||||
reticulocyte count | 1 | 33.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | angiomotin like 2 | VGNC:1731 | 460712 | |||||
Mouse | MGI:1929286 | 56332 | ||||||
Rat | RGD:70977 | 65157 | ||||||
Dog | angiomotin like 2 | VGNC:37837 | 485669 | |||||
Horse | angiomotin like 2 | VGNC:15282 | 100053062 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | angiomotin like 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | angiomotin like 2 | |||||
Horse | angiomotin like 2 | |||||
Publication Statistics
PubMed Score 25.86
PubMed score by year
PubTator Score 12.09
PubTator score by year
Related Publications
Text Mined References (28)
GeneRif Annotations (11)
Items per page:
0 of 0
PMID | Year | Title |
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