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Tbio
AMOTL1
Angiomotin-like protein 1

Protein Summary
Description
Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. The protein encoded by this gene is a peripheral membrane protein that is a component of tight junctions or TJs. TJs form an apical junctional structure and act to control paracellular permeability and maintain cell polarity. This protein is related to angiomotin, an angiostatin binding protein that regulates endothelial cell migration and capillary formation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317829
  • ENSP00000320968
  • ENSG00000166025
  • ENST00000433060
  • ENSP00000387739

Symbol
  • JEAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.68
transcription factor perturbation
0.68
microRNA
0.67
small molecule perturbation
0.61
cell type or tissue
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.36   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 120   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.36   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
MPP5
Tbio
Novelty:  0.01707773
p_int:  0.999912818
p_ni:  0.000087182
Score:  0.84
Data Source:  BioPlex,STRINGDB
NF2
Tbio
Novelty:  0.00055092
p_int:  0.999059884
p_ni:  0.000940116
Score:  0.918
Data Source:  BioPlex,STRINGDB
FHL3
Tbio
Novelty:  0.11505924
p_int:  0.998730064
p_ni:  0.001269936
Score:  0.181
Data Source:  BioPlex,STRINGDB
WWP2
Tbio
Family:  Enzyme
Novelty:  0.01935799
p_int:  0.998260433
p_ni:  0.001739553
p_wrong:  1.3e-8
Score:  0.25
Data Source:  BioPlex,STRINGDB
MAGEA4
Tbio
Novelty:  0.00949096
p_int:  0.99183575
p_ni:  0.00816425
Score:  0.167
Data Source:  BioPlex,STRINGDB
COG6
Tbio
Novelty:  0.02874093
p_int:  0.949174767
p_ni:  0.050825233
Data Source:  BioPlex
ALOX5
Tclin
Family:  Enzyme
Novelty:  0.00062988
p_int:  0.926347021
p_ni:  0.073651717
p_wrong:  0.000001262
Score:  0.165
Data Source:  BioPlex,STRINGDB
RNF166
Tdark
Novelty:  0.71460884
p_int:  0.87868252
p_ni:  0.12131748
Score:  0.224
Data Source:  BioPlex,STRINGDB
WWTR1
Tbio
Novelty:  0.00431186
Score:  0.986
Data Source:  Reactome,STRINGDB
YAP1
Tchem
Novelty:  0.00124225
Score:  0.985
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Signal Transduction (R-HSA-162582)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by Hippo
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by Hippo
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
angiomotin like 1
VGNC:3224
451491
Macaque
angiomotin like 1
698211
Mouse
MGI:1922973
75723
Dog
angiomotin like 1
VGNC:37836
485122
Horse
angiomotin like 1
VGNC:54256
100067270
Species
Name
OMA
EggNOG
Inparanoid
Chimp
angiomotin like 1
Macaque
angiomotin like 1
Mouse
Dog
angiomotin like 1
Horse
angiomotin like 1
Publication Statistics
PubMed Score 27.36
PubMed score by year
PubTator Score 14.80
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title