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Tbio
AMN
Protein amnionless

Protein Summary
Description
Necessary for efficient absorption of vitamin B12 (PubMed:12590260, PubMed:14576052). Required for normal CUBN-mediated protein transport in the kidney. May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm (By similarity). The protein encoded by this gene is a type I transmembrane protein. It is thought to modulate bone morphogenetic protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding. It is known that the mouse AMN gene is expressed in the extraembryonic visceral endoderm layer during gastrulation, but it is found to be mutated in amnionless mouse. The encoded protein has sequence similarity to short gastrulation (Sog) and procollagen IIA proteins in Drosophila. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299155
  • ENSP00000299155
  • ENSG00000166126

Symbol
  • PRO1028
  • amnionless
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.85
cellular component
0.74
gene perturbation
0.67
tissue sample
0.65
PubMedID
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.4   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 49   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.4   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (39)
CUBN
Tbio
Novelty:  0.00441944
Score:  0.993
Data Source:  Reactome,STRINGDB
GIF
Tbio
Novelty:  0.00508343
Score:  0.978
Data Source:  Reactome,STRINGDB
APOA1
Tbio
Novelty:  0.0001216
Score:  0.941
Data Source:  Reactome,STRINGDB
LRP2
Tbio
Novelty:  0.00143258
Score:  0.784
Data Source:  STRINGDB
ABCG4
Tbio
Family:  Transporter
Novelty:  0.02628545
Score:  0.673
Data Source:  STRINGDB
TCN2
Tbio
Novelty:  0.00213334
Score:  0.65
Data Source:  STRINGDB
DAB2
Tbio
Novelty:  0.00534123
Score:  0.646
Data Source:  STRINGDB
TCN1
Tbio
Novelty:  0.00305315
Score:  0.641
Data Source:  STRINGDB
CDC42BPB
Tchem
Family:  Kinase
Novelty:  0.12012285
Score:  0.621
Data Source:  STRINGDB
AMN1
Tbio
Novelty:  0.02370739
Score:  0.612
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (23)
Cobalamin (Cbl, vitamin B12) transport and metabolism (R-HSA-196741)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cobalamin (Cbl, vitamin B12) transport and metabolism
Reactome
Defective AMN causes hereditary megaloblastic anemia 1
Reactome
Defective CUBN causes hereditary megaloblastic anemia 1
Reactome
Defects in cobalamin (B12) metabolism
Reactome
Defects in vitamin and cofactor metabolism
Name
Explore in Pharos
Explore in Source
Cobalamin (Cbl, vitamin B12) transport and metabolism
Defective AMN causes hereditary megaloblastic anemia 1
Defective CUBN causes hereditary megaloblastic anemia 1
Defects in cobalamin (B12) metabolism
Defects in vitamin and cofactor metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
10
10
99.2
serum non-albumin protein measurement
1
4
4
93.2
lymphocyte count
3
3
3
92.7
lymphocyte percentage of leukocytes
2
2
2
89.6
body mass index
3
2
3
78.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
10
99.2
serum non-albumin protein measurement
4
93.2
lymphocyte count
3
92.7
lymphocyte percentage of leukocytes
2
89.6
body mass index
3
78.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
amnion associated transmembrane protein
VGNC:7430
453179
Mouse
MGI:1934943
93835
Rat
RGD:1308634
314459
Cow
amnion associated transmembrane protein
VGNC:25869
767976
Pig
amnion associated transmembrane protein
100157003
Species
Name
OMA
EggNOG
Inparanoid
Chimp
amnion associated transmembrane protein
Mouse
Rat
Cow
amnion associated transmembrane protein
Pig
amnion associated transmembrane protein
Publication Statistics
PubMed Score 28.40
PubMed score by year
PubTator Score 7.12
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title