Protein Summary
Necessary for efficient absorption of vitamin B12 (PubMed:12590260, PubMed:14576052). Required for normal CUBN-mediated protein transport in the kidney. May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm (By similarity). The protein encoded by this gene is a type I transmembrane protein. It is thought to modulate bone morphogenetic protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding. It is known that the mouse AMN gene is expressed in the extraembryonic visceral endoderm layer during gastrulation, but it is found to be mutated in amnionless mouse. The encoded protein has sequence similarity to short gastrulation (Sog) and procollagen IIA proteins in Drosophila. [provided by RefSeq, Jul 2008]
- ENST00000299155
- ENSP00000299155
- ENSG00000166126
- PRO1028
- amnionless
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
pathway | 0.85 | ||
cellular component | 0.74 | ||
gene perturbation | 0.67 | ||
tissue sample | 0.65 | ||
PubMedID | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 28.4 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 49 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 28.4 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 49 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (39)
Nearest Tclin Targets
Pathways (23)
Reactome (14)
WikiPathways (9)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cobalamin (Cbl, vitamin B12) transport and metabolism | ||||
Reactome | Defective AMN causes hereditary megaloblastic anemia 1 | ||||
Reactome | Defective CUBN causes hereditary megaloblastic anemia 1 | ||||
Reactome | Defects in cobalamin (B12) metabolism | ||||
Reactome | Defects in vitamin and cofactor metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cobalamin (Cbl, vitamin B12) transport and metabolism | ||||
Defective AMN causes hereditary megaloblastic anemia 1 | ||||
Defective CUBN causes hereditary megaloblastic anemia 1 | ||||
Defects in cobalamin (B12) metabolism | ||||
Defects in vitamin and cofactor metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (1)
Components (10)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Disease Associations ()
GWAS Traits (13)
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
serum gamma-glutamyl transferase measurement | 1 | 10 | 10 | 99.2 | |||||
serum non-albumin protein measurement | 1 | 4 | 4 | 93.2 | |||||
lymphocyte count | 3 | 3 | 3 | 92.7 | |||||
lymphocyte percentage of leukocytes | 2 | 2 | 2 | 89.6 | |||||
body mass index | 3 | 2 | 3 | 78.7 | |||||
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
serum gamma-glutamyl transferase measurement | 10 | 99.2 | |||||
serum non-albumin protein measurement | 4 | 93.2 | |||||
lymphocyte count | 3 | 92.7 | |||||
lymphocyte percentage of leukocytes | 2 | 89.6 | |||||
body mass index | 3 | 78.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | amnion associated transmembrane protein | VGNC:7430 | 453179 | |||||
Mouse | MGI:1934943 | 93835 | ||||||
Rat | RGD:1308634 | 314459 | ||||||
Cow | amnion associated transmembrane protein | VGNC:25869 | 767976 | |||||
Pig | amnion associated transmembrane protein | 100157003 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | amnion associated transmembrane protein | |||||
Mouse | ||||||
Rat | ||||||
Cow | amnion associated transmembrane protein | |||||
Pig | amnion associated transmembrane protein | |||||
Publication Statistics
PubMed Score 28.40
PubMed score by year
PubTator Score 7.12
PubTator score by year
Related Publications
Text Mined References (23)
GeneRif Annotations (10)
Items per page:
0 of 0
PMID | Year | Title |
|---|