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Tdark
AMIGO3
Amphoterin-induced protein 3

Protein Summary
Description
May mediate heterophilic cell-cell interaction. May contribute to signal transduction through its intracellular domain (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320431
  • ENSP00000323096
  • ENSG00000176020

Symbol
  • ALI3
  • KIAA1851
  • ALI3
  • AMIGO-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
tissue sample
0.65
kinase perturbation
0.54
cell type or tissue
0.51
histone modification site profile
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.51   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.51   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (15)
GTPBP8
Tdark
Novelty:  4.38933188
p_int:  0.999992525
p_ni:  0.000007412
p_wrong:  6.3e-8
Score:  0.189
Data Source:  BioPlex,STRINGDB
TMEM268
Tdark
Novelty:  4.79855247
p_int:  0.999940745
p_ni:  0.000038909
p_wrong:  0.000020347
Score:  0.199
Data Source:  BioPlex,STRINGDB
GOLPH3
Tbio
Novelty:  0.00020234
p_int:  0.996563632
p_ni:  0.003436326
p_wrong:  4.1e-8
Data Source:  BioPlex
PTPRK
Tbio
Family:  Enzyme
Novelty:  0.03149943
p_int:  0.987693733
p_ni:  0.012281327
p_wrong:  0.00002494
Data Source:  BioPlex
C1QL4
Tdark
Novelty:  0.37071722
p_int:  0.9679713
p_ni:  0.03202861
p_wrong:  8.9e-8
Data Source:  BioPlex
FBXO2
Tbio
Novelty:  0.01578361
p_int:  0.966122855
p_ni:  0.033877133
p_wrong:  1.1e-8
Data Source:  BioPlex
SEL1L
Tbio
Novelty:  0.01198173
p_int:  0.957591886
p_ni:  0.042408114
Score:  0.163
Data Source:  BioPlex,STRINGDB
UFSP2
Tbio
Family:  Enzyme
Novelty:  0.12630722
p_int:  0.952669845
p_ni:  0.047330155
Data Source:  BioPlex
CANX
Tbio
Novelty:  0.00087002
p_int:  0.930157728
p_ni:  0.069842272
Data Source:  BioPlex
SLC22A18
Tbio
Family:  Transporter
Novelty:  0.0189809
p_int:  0.89633032
p_ni:  0.1036246
p_wrong:  0.000045079
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (36)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
5
5
4
8.2
98.6
intelligence
4
8
3
7.4
96.1
reticulocyte count
1
2
2
93.4
mathematical ability
3
3
3
92.6
household income
2
4
5
92.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
8.2
98.6
intelligence
3
7.4
96.1
reticulocyte count
2
93.4
mathematical ability
3
92.6
household income
5
92.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adhesion molecule with Ig like domain 3
VGNC:2585
104005563
Macaque
adhesion molecule with Ig like domain 3
705693
Mouse
MGI:2444854
320844
Dog
adhesion molecule with Ig like domain 3
VGNC:37833
102156324
Horse
adhesion molecule with Ig like domain 3
VGNC:15279
102151043
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adhesion molecule with Ig like domain 3
Macaque
adhesion molecule with Ig like domain 3
Mouse
Dog
adhesion molecule with Ig like domain 3
Horse
adhesion molecule with Ig like domain 3
Publication Statistics
PubMed Score 1.51
PubMed score by year
PubTator Score 11.64
PubTator score by year
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Related Publications
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PMID
Year
Title