Tbio AMIGO2 Amphoterin-induced protein 2

Protein Summary

Description

Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.

Uniprot Accession IDs

• Q86SJ2
• Q4VBP6
• Q7Z4A0
• Q96CN8

Gene Name

• AMIGO2

Ensembl ID

• ENST00000266581
• ENSP00000266581
• ENSG00000139211
• ENST00000429635
• ENSP00000406020
• ENST00000550413
• ENSP00000449034

Symbol

• ALI1
• ALI1
• DEGA
• AMIGO-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
small molecule perturbation	0.91
PubMedID	0.89
transcription factor perturbation	0.84
gene perturbation	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.01   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 224   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.01   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 224   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0