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Tbio
AMIGO1
Amphoterin-induced protein 1

Protein Summary
Description
Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369862
  • ENSP00000358878
  • ENSG00000181754
  • ENST00000369864
  • ENSP00000358880

Symbol
  • ALI2
  • AMIGO
  • KIAA1163
  • ALI2
  • AMIGO
  • AMIGO-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
histone modification site profile
0.79
cell type or tissue
0.58
cell line
0.56
tissue
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.95   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 298   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.95   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 298   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
CNPY3
Tbio
Novelty:  0.11473132
p_int:  0.999925135
p_ni:  0.000074865
Data Source:  BioPlex
LRRTM1
Tbio
Novelty:  0.0409182
p_int:  0.997955858
p_ni:  0.002044127
p_wrong:  1.5e-8
Score:  0.186
Data Source:  BioPlex,STRINGDB
ADAM21
Tdark
Family:  Enzyme
Novelty:  0.16068055
p_int:  0.997926733
p_ni:  0.002073249
p_wrong:  1.7e-8
Data Source:  BioPlex
NOP9
Tdark
Novelty:  2.89535198
p_int:  0.997679197
p_ni:  0.002320803
Data Source:  BioPlex
TMPRSS12
Tdark
Family:  Enzyme
Novelty:  0.38051198
p_int:  0.997136748
p_ni:  0.002863249
p_wrong:  3e-9
Data Source:  BioPlex
PON2
Tbio
Family:  Enzyme
Novelty:  0.00414855
p_int:  0.995494913
p_ni:  0.00450508
p_wrong:  6e-9
Score:  0.152
Data Source:  BioPlex,STRINGDB
NCEH1
Tchem
Family:  Enzyme
Novelty:  0.01528589
p_int:  0.993534864
p_ni:  0.00638644
p_wrong:  0.000078696
Score:  0.17
Data Source:  BioPlex,STRINGDB
CD1B
Tbio
Novelty:  0.00102701
p_int:  0.993094237
p_ni:  0.006901975
p_wrong:  0.000003788
Data Source:  BioPlex
MPPE1
Tbio
Family:  Enzyme
Novelty:  0.16027847
p_int:  0.992950884
p_ni:  0.007017778
p_wrong:  0.000031338
Data Source:  BioPlex
PICK1
Tbio
Novelty:  0.0058265
p_int:  0.98734314
p_ni:  0.012656833
p_wrong:  2.8e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
2
9
9
98.1
low density lipoprotein cholesterol measurement
2
8
9
96.6
body mass index
7
3
8
94.3
total cholesterol measurement
1
5
5
91.7
self reported educational attainment
4
4
3
6.3
90.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
9
98.1
low density lipoprotein cholesterol measurement
9
96.6
body mass index
8
94.3
total cholesterol measurement
5
91.7
self reported educational attainment
3
6.3
90.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adhesion molecule with Ig like domain 1
VGNC:12981
739969
Macaque
adhesion molecule with Ig like domain 1
698932
Mouse
MGI:2653612
229715
Rat
RGD:1303079
295365
Dog
adhesion molecule with Ig like domain 1
VGNC:37831
490120
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adhesion molecule with Ig like domain 1
Macaque
adhesion molecule with Ig like domain 1
Mouse
Rat
Dog
adhesion molecule with Ig like domain 1
Publication Statistics
PubMed Score 106.95
PubMed score by year
PubTator Score 34.00
PubTator score by year
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Related Publications
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PMID
Year
Title