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Tbio
AMHR2
Anti-Muellerian hormone type-2 receptor

Protein Summary
Description
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. This gene encodes the receptor for the anti-Mullerian hormone (AMH) which, in addition to testosterone, results in male sex differentiation. AMH and testosterone are produced in the testes by different cells and have different effects. Testosterone promotes the development of male genitalia while the binding of AMH to the encoded receptor prevents the development of the mullerian ducts into uterus and Fallopian tubes. Mutations in this gene are associated with persistent Mullerian duct syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257863
  • ENSP00000257863
  • ENSG00000135409
  • ENST00000379791
  • ENSP00000369117
  • ENST00000550311
  • ENSP00000446661

Symbol
  • AMHR
  • MISR2
  • AMHR
  • MRII
  • MISR2
  • MISRII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
0.73
cell type or tissue
0.63
virus perturbation
0.55
cell line
0.52


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 232.2   (req: < 5)
Gene RIFs: 44   (req: <= 3)
Antibodies: 301   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 232.2   (req: >= 5)
Gene RIFs: 44   (req: > 3)
Antibodies: 301   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
AMH
Tbio
Novelty:  0.00022501
Score:  0.993
Data Source:  Reactome,STRINGDB
SMAD5
Tbio
Family:  TF
Novelty:  0.00405952
Score:  0.949
Data Source:  STRINGDB
ACVR1
Tchem
Family:  Kinase
Novelty:  0.00284646
Score:  0.946
Data Source:  STRINGDB
SMAD9
Tbio
Family:  TF
Novelty:  0.00285887
Score:  0.943
Data Source:  STRINGDB
SMAD1
Tbio
Family:  TF
Novelty:  0.02348173
Score:  0.928
Data Source:  STRINGDB
FKBP1A
Tclin
Family:  Enzyme
Novelty:  0.00116174
Score:  0.921
Data Source:  STRINGDB
BMPR2
Tchem
Family:  Kinase
Novelty:  0.00155912
Score:  0.819
Data Source:  STRINGDB
BMP4
Tchem
Novelty:  0.00047387
Score:  0.787
Data Source:  STRINGDB
BMP2
Tbio
Novelty:  0.00016974
Score:  0.786
Data Source:  STRINGDB
BMP6
Tbio
Novelty:  0.00197133
Score:  0.765
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Signal Transduction (R-HSA-162582)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by BMP
Reactome
Signaling by TGF-beta family members
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by BMP
Signaling by TGF-beta family members
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bone density
3
2
4
91.2
mean corpuscular volume
3
3
3
86.3
heel bone mineral density
2
3
3
86
alkaline phosphatase measurement
2
1
1
8.8
83.8
body height
1
1
1
81.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bone density
4
91.2
mean corpuscular volume
3
86.3
heel bone mineral density
3
86
alkaline phosphatase measurement
1
8.8
83.8
body height
1
81.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
anti-Mullerian hormone receptor type 2
VGNC:8316
467005
Macaque
anti-Mullerian hormone receptor type 2
702822
Mouse
MGI:105062
110542
Rat
RGD:70964
29530
Dog
anti-Mullerian hormone receptor type 2
VGNC:37830
486506
Species
Name
OMA
EggNOG
Inparanoid
Chimp
anti-Mullerian hormone receptor type 2
Macaque
anti-Mullerian hormone receptor type 2
Mouse
Rat
Dog
anti-Mullerian hormone receptor type 2
Publication Statistics
PubMed Score 232.20
PubMed score by year
PubTator Score 65.89
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title