You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
AMFR
E3 ubiquitin-protein ligase AMFR

Protein Summary
Description
E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor. This locus encodes a glycosylated transmembrane receptor. Its ligand, autocrine motility factor, i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290649
  • ENSP00000290649
  • ENSG00000159461

Symbol
  • RNF45
  • GP78
  • RNF45
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.98
kinase perturbation
0.95
PubMedID
0.92
cellular component
0.84
cell type or tissue
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 224.34   (req: < 5)
Gene RIFs: 50   (req: <= 3)
Antibodies: 268   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 224.34   (req: >= 5)
Gene RIFs: 50   (req: > 3)
Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0