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Tbio
AMELX
Amelogenin, X isoform

Protein Summary
Description
Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. This gene encodes a member of the amelogenin family of extracellular matrix proteins. Amelogenins are involved in biomineralization during tooth enamel development. Mutations in this gene cause X-linked amelogenesis imperfecta. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000348912
  • ENSP00000335312
  • ENSG00000125363
  • ENST00000380712
  • ENSP00000370088
  • ENST00000380714
  • ENSP00000370090

Symbol
  • AMG
  • AMGX
  • AMG
  • AI1E
  • AIH1
  • ALGN
  • AMGL
  • AMGX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.62
biological term
0.56
biological process
0.51
disease
0.51
tissue
0.47


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1662.43   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1662.43   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (163)
ENAM
Tbio
Novelty:  0.00593293
Score:  0.995
Data Source:  STRINGDB
AMBN
Tbio
Novelty:  0.00354946
Score:  0.995
Data Source:  STRINGDB
FGA
Tbio
Novelty:  0.00107227
Score:  0.983
Data Source:  STRINGDB
AMTN
Tbio
Novelty:  0.02514528
Score:  0.982
Data Source:  STRINGDB
FAM20C
Tbio
Family:  Enzyme
Novelty:  0.00318966
Score:  0.974
Data Source:  STRINGDB
FAM20A
Tbio
Family:  Enzyme
Novelty:  0.03742119
Score:  0.963
Data Source:  STRINGDB
SPP1
Tbio
Novelty:  0.00014418
Score:  0.945
Data Source:  STRINGDB
MEPE
Tbio
Novelty:  0.00825085
Score:  0.941
Data Source:  STRINGDB
SPARCL1
Tbio
Novelty:  0.01077806
Score:  0.94
Data Source:  STRINGDB
DMP1
Tbio
Novelty:  0.03114505
Score:  0.938
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of proteins (R-HSA-392499)

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Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Post-translational protein phosphorylation
Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
Post-translational protein phosphorylation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
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Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
49.5
2
1
0
1.1
45.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
49.5
0
1.1
45.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
amelogenin X-linked
VGNC:2731
473517
Macaque
amelogenin, X-linked
710057
Dog
amelogenin, X-linked
100683823
Horse
amelogenin, X-linked
100049799
Cow
amelogenin, X-linked
281620
Species
Name
OMA
EggNOG
Inparanoid
Chimp
amelogenin X-linked
Macaque
amelogenin, X-linked
Dog
amelogenin, X-linked
Horse
amelogenin, X-linked
Cow
amelogenin, X-linked
Publication Statistics
PubMed Score 1662.43
PubMed score by year
PubTator Score 197.66
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title