Protein Summary
Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization. Trypstatin is a trypsin inhibitor. This gene encodes a complex glycoprotein secreted in plasma. The precursor is proteolytically processed into distinct functioning proteins: alpha-1-microglobulin, which belongs to the superfamily of lipocalin transport proteins and may play a role in the regulation of inflammatory processes, and bikunin, which is a urinary trypsin inhibitor belonging to the superfamily of Kunitz-type protease inhibitors and plays an important role in many physiological and pathological processes. This gene is located on chromosome 9 in a cluster of lipocalin genes. [provided by RefSeq, Jul 2008]
- ENST00000265132
- ENSP00000265132
- ENSG00000106927
- HCP
- ITIL
- A1M
- HCP
- ITI
- UTI
- EDC1
- HI30
- ITIL
- IATIL
- ITILC
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.99 | ||
molecular function | 0.91 | ||
biological process | 0.82 | ||
gene perturbation | 0.77 | ||
disease perturbation | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 523.35 (req: < 5)
Gene RIFs: 53 (req: <= 3)
Antibodies: 510 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 523.35 (req: >= 5)
Gene RIFs: 53 (req: > 3)
Antibodies: 510 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (142)
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Binding and Uptake of Ligands by Scavenger Receptors | ||||
Reactome | Scavenging of heme from plasma | ||||
Reactome | Vesicle-mediated transport | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Binding and Uptake of Ligands by Scavenger Receptors | ||||
Scavenging of heme from plasma | ||||
Vesicle-mediated transport | ||||
Viral Interactions (0)
Gene Ontology Terms (23)
Functions (6)
Components (8)
Processes (9)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
3 | 2 | 0 | 1.1 | 54.3 | |||||
balding measurement | 1 | 1 | 1 | 30.2 | |||||
lifestyle measurement | 1 | 1 | 1 | 27.3 | |||||
Knee pain | 1 | 2 | 2 | 27.3 | |||||
serum metabolite measurement | 1 | 1 | 1 | 21.5 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.1 | 54.3 | |||||
balding measurement | 1 | 30.2 | |||||
lifestyle measurement | 1 | 27.3 | |||||
Knee pain | 2 | 27.3 | |||||
serum metabolite measurement | 1 | 21.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:88002 | 11699 | ||||||
Rat | RGD:2102 | 25377 | ||||||
Dog | alpha-1-microglobulin/bikunin precursor | VGNC:51697 | 481685 | |||||
Horse | alpha-1-microglobulin/bikunin precursor | 100051766 | ||||||
Cow | alpha-1-microglobulin/bikunin precursor | 280996 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | alpha-1-microglobulin/bikunin precursor | |||||
Horse | alpha-1-microglobulin/bikunin precursor | |||||
Cow | alpha-1-microglobulin/bikunin precursor | |||||
Publication Statistics
PubMed Score 523.35
PubMed score by year
PubTator Score 517.02
PubTator score by year
Related Publications
Text Mined References (113)
GeneRif Annotations (53)
Items per page:
0 of 0
PMID | Year | Title |
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