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Tbio
AMBN
Ameloblastin

Protein Summary
Description
Involved in the mineralization and structural organization of enamel. This gene encodes the nonamelogenin enamel matrix protein ameloblastin. The encoded protein may be important in enamel matrix formation and mineralization. This gene is located in the calcium-binding phosphoprotein gene cluster on chromosome 4. Mutations in this gene may be associated with dentinogenesis imperfect and autosomal dominant amylogenesis imperfect. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322937
  • ENSP00000313809
  • ENSG00000178522
  • ENST00000449493
  • ENSP00000391234

Symbol
  • AI1F
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.86
virus perturbation
0.76
cell line
0.56
tissue
0.54
cellular component
0.48


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 274.32   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 274.32   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (152)
UBAC1
Tbio
Novelty:  0.00122518
p_int:  0.920439886
p_ni:  0.073674525
p_wrong:  0.005885589
Score:  0.239
Data Source:  BioPlex,STRINGDB
LRP2
Tbio
Novelty:  0.00143258
p_int:  0.914889671
p_ni:  0.085110329
Score:  0.238
Data Source:  BioPlex,STRINGDB
AMELX
Tbio
Novelty:  0.00063284
Score:  0.995
Data Source:  STRINGDB
ENAM
Tbio
Novelty:  0.00593293
Score:  0.992
Data Source:  STRINGDB
AMTN
Tbio
Novelty:  0.02514528
Score:  0.987
Data Source:  STRINGDB
SPARCL1
Tbio
Novelty:  0.01077806
Score:  0.972
Data Source:  STRINGDB
FAM20A
Tbio
Family:  Enzyme
Novelty:  0.03742119
Score:  0.972
Data Source:  STRINGDB
FAM20C
Tbio
Family:  Enzyme
Novelty:  0.00318966
Score:  0.971
Data Source:  STRINGDB
MEPE
Tbio
Novelty:  0.00825085
Score:  0.951
Data Source:  STRINGDB
DMP1
Tbio
Novelty:  0.03114505
Score:  0.951
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Post-translational protein phosphorylation
Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
Post-translational protein phosphorylation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body fat percentage
1
1
1
14.2
serum metabolite measurement
1
1
1
8.4
1
1
0
32.4
2.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body fat percentage
1
14.2
serum metabolite measurement
1
8.4
0
32.4
2.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ameloblastin
VGNC:559
741969
Macaque
ameloblastin
706845
Mouse
MGI:104655
11698
Rat
RGD:2101
25376
Dog
ameloblastin
VGNC:37825
482185
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ameloblastin
Macaque
ameloblastin
Mouse
Rat
Dog
ameloblastin
Publication Statistics
PubMed Score 274.32
PubMed score by year
PubTator Score 105.81
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title