Tbio AMBN Ameloblastin

Protein Summary

Description

Involved in the mineralization and structural organization of enamel. This gene encodes the nonamelogenin enamel matrix protein ameloblastin. The encoded protein may be important in enamel matrix formation and mineralization. This gene is located in the calcium-binding phosphoprotein gene cluster on chromosome 4. Mutations in this gene may be associated with dentinogenesis imperfect and autosomal dominant amylogenesis imperfect. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• Q9NP70
• Q3B862
• Q9H2X1
• Q9H4L1

Gene Name

• AMBN

Ensembl ID

• ENST00000322937
• ENSP00000313809
• ENSG00000178522
• ENST00000449493
• ENSP00000391234

Symbol

• AI1F

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.86
virus perturbation	0.76
cell line	0.56
tissue	0.54
cellular component	0.48

Protein Classes

PANTHER Classes

Protein / Structural Protein / Ameloblastin

Protein / Extracellular Matrix Protein / Ameloblastin

DTO Classes

Protein / Cellular Structure / Ameloblastin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 293.2   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 116   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 293.2   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0