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Tbio
AMACR
Alpha-methylacyl-CoA racemase

Protein Summary
Description
Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers. This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene. [provided by RefSeq, Mar 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335606
  • ENSP00000334424
  • ENSG00000242110
  • ENST00000382072
  • ENSP00000371504
  • ENST00000382085
  • ENSP00000371517
  • ENST00000506639
  • ENSP00000427227

Symbol
  • RM
  • RACE
  • CBAS4
  • P504S
  • AMACRD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
transcription factor binding site profile
0.74
biological term
0.7
cellular component
0.68
disease perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 510.49   (req: < 5)
Gene RIFs: 90   (req: <= 3)
Antibodies: 827   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 510.49   (req: >= 5)
Gene RIFs: 90   (req: > 3)
Antibodies: 827   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (126)
FKBP5
Tchem
Family:  Enzyme
Novelty:  0.00214511
p_int:  0.999959884
p_ni:  0.000040116
Score:  0.234
Data Source:  BioPlex,STRINGDB
HSP90AA5P
Tdark
p_int:  0.999590945
p_ni:  0.000409055
Data Source:  BioPlex
PSMG3
Tchem
Novelty:  0.01730294
p_int:  0.996645355
p_ni:  0.003354644
Score:  0.189
Data Source:  BioPlex,STRINGDB
PSMG4
Tdark
Novelty:  0.05339077
p_int:  0.902617906
p_ni:  0.097378701
p_wrong:  0.000003393
Score:  0.228
Data Source:  BioPlex,STRINGDB
ACOX2
Tbio
Family:  Enzyme
Novelty:  0.02942359
Score:  0.983
Data Source:  STRINGDB
ACOX3
Tchem
Family:  Enzyme
Novelty:  0.04077258
Score:  0.982
Data Source:  STRINGDB
HSD17B4
Tbio
Novelty:  0.00547499
Score:  0.971
Data Source:  STRINGDB
ACOT8
Tbio
Family:  Enzyme
Novelty:  0.02218214
Score:  0.966
Data Source:  STRINGDB
EHHADH
Tbio
Novelty:  0.00878193
Score:  0.966
Data Source:  STRINGDB
LONP2
Tbio
Family:  Enzyme
Novelty:  0.04499043
Score:  0.964
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Beta-oxidation of pristanoyl-CoA (R-HSA-389887)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-oxidation of pristanoyl-CoA
Reactome
Bile acid and bile salt metabolism
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Beta-oxidation of pristanoyl-CoA
Bile acid and bile salt metabolism
Fatty acid metabolism
Metabolism
Metabolism of lipids
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
4
5
2
3.3
99.3
suntan
2
2
2
95.7
3
2
1
1.6
92
skin pigmentation measurement
3
3
4
90.8
2
2
0
1.8
89.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
2
3.3
99.3
suntan
2
95.7
1
1.6
92
skin pigmentation measurement
4
90.8
0
1.8
89.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
alpha-methylacyl-CoA racemase
698365
Mouse
MGI:1098273
17117
Rat
RGD:3048
25284
Dog
alpha-methylacyl-CoA racemase
VGNC:37824
612603
Cow
alpha-methylacyl-CoA racemase
VGNC:25856
540376
Species
Name
OMA
EggNOG
Inparanoid
Macaque
alpha-methylacyl-CoA racemase
Mouse
Rat
Dog
alpha-methylacyl-CoA racemase
Cow
alpha-methylacyl-CoA racemase
Publication Statistics
PubMed Score 510.49
PubMed score by year
PubTator Score 316.63
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title