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Tbio
ALX3
Homeobox protein aristaless-like 3

Protein Summary
Description
Transcriptional regulator with a possible role in patterning of mesoderm during development. This gene encodes a nuclear protein with a homeobox DNA-binding domain that functions as a transcriptional regulator involved in cell-type differentiation and development. Preferential methylation of this gene's promoter is associated with advanced-stage neuroblastoma tumors. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369792
  • ENSP00000358807
  • ENSG00000156150
  • ENST00000647563
  • ENSP00000497310

Symbol
  • FND
  • FND1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.82
PubMedID
0.6
biological process
0.55
tissue
0.54
phenotype
0.5


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.36   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.36   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
P3H2
Tbio
Family:  Enzyme
Novelty:  0.04237396
p_int:  0.999997058
p_ni:  0.000002942
Score:  0.158
Data Source:  BioPlex,STRINGDB
NDUFAF7
Tbio
Family:  Enzyme
Novelty:  0.24691414
p_int:  0.999648082
p_ni:  0.000351918
Data Source:  BioPlex
KBTBD7
Tdark
Novelty:  0.4947466
p_int:  0.997956432
p_ni:  0.002043567
p_wrong:  1e-9
Data Source:  BioPlex
CRTAP
Tbio
Novelty:  0.02380647
p_int:  0.996042436
p_ni:  0.003957564
Score:  0.313
Data Source:  BioPlex,STRINGDB
IKBIP
Tbio
Family:  Enzyme
Novelty:  0.18707639
p_int:  0.99515683
p_ni:  0.00484317
Data Source:  BioPlex
MOCS3
Tbio
Family:  Enzyme
Novelty:  0.039209
p_int:  0.994175312
p_ni:  0.005824688
Score:  0.189
Data Source:  BioPlex,STRINGDB
SUPT16H
Tbio
Family:  Enzyme
Novelty:  0.01026868
p_int:  0.984797409
p_ni:  0.015202591
Score:  0.172
Data Source:  BioPlex,STRINGDB
C18orf25
Tdark
Novelty:  0.67505268
p_int:  0.983681543
p_ni:  0.016318442
p_wrong:  1.5e-8
Data Source:  BioPlex
UBN2
Tbio
Novelty:  0.09777456
p_int:  0.9633365
p_ni:  0.014387538
p_wrong:  0.022275962
Score:  0.167
Data Source:  BioPlex,STRINGDB
PRKAR2B
Tchem
Family:  Enzyme
Novelty:  0.00456972
p_int:  0.948893959
p_ni:  0.051105094
p_wrong:  9.47e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
1
3
64.9
self reported educational attainment
1
1
1
62.1
cognitive function measurement
1
1
1
46.9
age at first sexual intercourse measurement
1
1
1
38.8
optic disc size measurement
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
64.9
self reported educational attainment
1
62.1
cognitive function measurement
1
46.9
age at first sexual intercourse measurement
1
38.8
optic disc size measurement
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ALX homeobox 3
VGNC:81
469416
Mouse
MGI:1277097
11694
Rat
RGD:1359270
365900
Dog
ALX homeobox 3
VGNC:37821
611786
Horse
ALX homeobox 3
VGNC:15271
100058414
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ALX homeobox 3
Mouse
Rat
Dog
ALX homeobox 3
Horse
ALX homeobox 3
Publication Statistics
PubMed Score 41.36
PubMed score by year
PubTator Score 105.58
PubTator score by year
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Related Publications
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PMID
Year
Title