Tbio ALS2CL ALS2 C-terminal-like protein

Protein Summary

Description

Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics.

Uniprot Accession IDs

• Q60I27
• Q32MA1
• Q6AI56
• Q6ZNC5
• Q6ZNC7
• Q6ZTL4
• Q86YD2
• Q8N9U1
• Q8NAL7

Gene Name

• ALS2CL

Ensembl ID

• ENST00000318962
• ENSP00000313670
• ENSG00000178038
• ENST00000415953
• ENSP00000413223

Symbol

• RN49018

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.91
virus perturbation	0.88
small molecule perturbation	0.7
histone modification site profile	0.65
molecular function	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.85   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 84   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.85   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0