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Tbio
ALPP
Alkaline phosphatase, placental type

Protein Summary
Description
The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. The protein is primarily expressed in placental and endometrial tissue; however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. [provided by RefSeq, Jan 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392027
  • ENSP00000375881
  • ENSG00000163283

Symbol
  • PLAP
  • ALP
  • IAP
  • ALPI
  • PALP
  • PLAP
  • PLAP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.68
gene perturbation
0.67
protein domain
0.58
biological term
0.56
cellular component
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 278.54   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 1497   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 278.54   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 1497   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
ALPG
Tchem
Family:  Enzyme
Novelty:  0.00577814
p_int:  1
Score:  0.873
Data Source:  BioPlex,STRINGDB
ALPI
Tchem
Family:  Enzyme
Novelty:  0.00559196
p_int:  0.999999547
p_ni:  4.53e-7
Score:  0.855
Data Source:  BioPlex,STRINGDB
PTS
Tbio
Family:  Enzyme
Novelty:  0.00279396
Score:  0.913
Data Source:  STRINGDB
GCH1
Tbio
Family:  Enzyme
Novelty:  0.0025793
Score:  0.91
Data Source:  STRINGDB
NTPCR
Tbio
Family:  Enzyme
Novelty:  0.0638186
Score:  0.908
Data Source:  STRINGDB
TPK1
Tbio
Family:  Kinase
Novelty:  0.00899463
Score:  0.901
Data Source:  STRINGDB
TRIP11
Tbio
Novelty:  0.03011344
Score:  0.9
Data Source:  STRINGDB
ARF1
Tchem
Family:  Enzyme
Novelty:  0.00208554
Score:  0.9
Data Source:  STRINGDB
GGT7
Tbio
Family:  Enzyme
Novelty:  0.01374716
Score:  0.713
Data Source:  STRINGDB
GGT6
Tbio
Family:  Enzyme
Novelty:  0.016069
Score:  0.697
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Intra-Golgi and retrograde Golgi-to-ER traffic (R-HSA-6811442)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Intra-Golgi traffic
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Intra-Golgi and retrograde Golgi-to-ER traffic
Intra-Golgi traffic
Membrane Trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
3
9
10
82.2
BMI-adjusted hip circumference
2
5
6
71.4
body height
1
1
1
31.4
refractive error measurement
1
1
1
26.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
10
82.2
BMI-adjusted hip circumference
6
71.4
body height
1
31.4
refractive error measurement
1
26.1
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
alkaline phosphatase, placental
VGNC:61
470679
Rat
RGD:2099
24197
Cow
alkaline phosphatase, intestinal
280993
Xenopus
alkaline phosphatase, intestinal, gene 1
XB-GENE-854726
548375
Zebrafish
ZDB-GENE-050626-142
574009
Species
Name
OMA
EggNOG
Inparanoid
Chimp
alkaline phosphatase, placental
Rat
Cow
alkaline phosphatase, intestinal
Xenopus
alkaline phosphatase, intestinal, gene 1
Zebrafish
Publication Statistics
PubMed Score 278.54
PubMed score by year
PubTator Score 3633.12
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title