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Tchem
ALPL
Alkaline phosphatase, tissue-nonspecific isozyme

Protein Summary
Description
This isozyme may play a role in skeletal mineralization. This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects. [provided by RefSeq, Oct 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374832
  • ENSP00000363965
  • ENSG00000162551
  • ENST00000374840
  • ENSP00000363973
  • ENST00000539907
  • ENSP00000437674
  • ENST00000540617
  • ENSP00000442672

Symbol
  • HOPS
  • TNAP
  • TNALP
  • APTNAP
  • TNSALP
  • AP-TNAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.91
chemical
0.87
phenotype
0.85
PubMedID
0.79
transcription factor binding site profile
0.74


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 702.76   (req: < 5)
Gene RIFs: 152   (req: <= 3)
Antibodies: 934   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 702.76   (req: >= 5)
Gene RIFs: 152   (req: > 3)
Antibodies: 934   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 116
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (242)
SPCS2
Tdark
Family:  Enzyme
Novelty:  0.21358992
p_int:  0.935471853
p_ni:  0.064528147
Score:  0.823
Data Source:  BioPlex,STRINGDB
SEC11C
Tdark
Family:  Enzyme
Novelty:  0.19577003
p_int:  0.919636988
p_ni:  0.080137178
p_wrong:  0.000225834
Score:  0.835
Data Source:  BioPlex,STRINGDB
ENPP1
Tchem
Family:  Enzyme
Novelty:  0.00256132
Score:  0.973
Data Source:  STRINGDB
IBSP
Tbio
Novelty:  0.00092598
Score:  0.963
Data Source:  STRINGDB
THY1
Tbio
Novelty:  0.00032846
Score:  0.953
Data Source:  STRINGDB
GPLD1
Tbio
Family:  Enzyme
Novelty:  0.00627091
Score:  0.947
Data Source:  STRINGDB
COL4A1
Tbio
Novelty:  0.00358049
Score:  0.913
Data Source:  STRINGDB
PTS
Tbio
Family:  Enzyme
Novelty:  0.00279396
Score:  0.913
Data Source:  STRINGDB
XPNPEP2
Tchem
Family:  Enzyme
Novelty:  0.01453123
Score:  0.911
Data Source:  STRINGDB
GCH1
Tbio
Family:  Enzyme
Novelty:  0.0025793
Score:  0.91
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (30)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
6
9
7
19.4
99.7
heel bone mineral density
2
3
4
90.5
phosphorus measurement
2
3
3
89.7
reticulocyte count
4
2
4
87.3
vitamin B6 measurement
2
2
2
78.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
7
19.4
99.7
heel bone mineral density
4
90.5
phosphorus measurement
3
89.7
reticulocyte count
4
87.3
vitamin B6 measurement
2
78.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
alkaline phosphatase, liver/bone/kidney
456600
Macaque
alkaline phosphatase, liver/bone/kidney
717809
Mouse
MGI:87983
11647
Rat
RGD:2100
25586
Dog
alkaline phosphatase, liver/bone/kidney
VGNC:37818
403548
Species
Name
OMA
EggNOG
Inparanoid
Chimp
alkaline phosphatase, liver/bone/kidney
Macaque
alkaline phosphatase, liver/bone/kidney
Mouse
Rat
Dog
alkaline phosphatase, liver/bone/kidney
Publication Statistics
PubMed Score 702.76
PubMed score by year
PubTator Score 265.39
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title