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Tchem
ALPI
Intestinal-type alkaline phosphatase

Protein Summary
Description
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The intestinal alkaline phosphatase gene encodes a digestive brush-border enzyme. This enzyme is a component of the gut mucosal defense system and is thought to function in the detoxification of lipopolysaccharide, and in the prevention of bacterial translocation in the gut. [provided by RefSeq, Dec 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295463
  • ENSP00000295463
  • ENSG00000163295

Symbol
  • IAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.68
cell type or tissue
0.6
molecular function
0.6
cellular component
0.58
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 173.37   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 694   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 173.37   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 694   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 19
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (148)
ALPG
Tchem
Family:  Enzyme
Novelty:  0.00577814
p_int:  0.999999981
p_ni:  1.9e-8
Score:  0.968
Data Source:  BioPlex,STRINGDB
ALPP
Tbio
Family:  Enzyme
Novelty:  0.0037276
p_int:  0.999999547
p_ni:  4.53e-7
Score:  0.855
Data Source:  BioPlex,STRINGDB
ARL2
Tbio
Family:  Enzyme
Novelty:  0.01989908
p_int:  0.999955728
p_ni:  0.000044238
p_wrong:  3.4e-8
Score:  0.188
Data Source:  BioPlex,STRINGDB
TUBB1
Tclin
Novelty:  0.02806117
p_int:  0.999815665
p_ni:  0.000184335
Score:  0.164
Data Source:  BioPlex,STRINGDB
ARF5
Tbio
Family:  Enzyme
Novelty:  0.02454098
p_int:  0.972322958
p_ni:  0.027677011
p_wrong:  3.1e-8
Score:  0.175
Data Source:  BioPlex,STRINGDB
DDX19B
Tbio
Family:  Enzyme
Novelty:  0.0504568
p_int:  0.933250615
p_ni:  0.066749385
Data Source:  BioPlex
RAB39B
Tbio
Family:  Enzyme
Novelty:  0.02362498
p_int:  0.928263198
p_ni:  0.071736801
p_wrong:  1e-9
Score:  0.175
Data Source:  BioPlex,STRINGDB
RDH13
Tbio
Family:  Enzyme
Novelty:  0.20184998
p_int:  0.862365471
p_ni:  0.137634528
Score:  0.191
Data Source:  BioPlex,STRINGDB
ARL8B
Tbio
Family:  Enzyme
Novelty:  0.06939851
p_int:  0.834605267
p_ni:  0.165335066
p_wrong:  0.000059667
Score:  0.181
Data Source:  BioPlex,STRINGDB
THY1
Tbio
Novelty:  0.00032846
Score:  0.921
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Digestion (R-HSA-8935690)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Digestion
Reactome
Digestion and absorption
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Digestion
Digestion and absorption
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
3
6
7
12.7
98.1
Myopia
3
2
0
1.3
86.9
corneal topography
2
1
2
83.9
age at onset
1
1
0
12.7
81.9
BMI-adjusted waist circumference
1
4
4
78
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
7
12.7
98.1
Myopia
0
1.3
86.9
corneal topography
2
83.9
age at onset
0
12.7
81.9
BMI-adjusted waist circumference
4
78
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Anole lizard
alkaline phosphatase, intestinal
100566185
Xenopus
alkaline phosphatase, intestinal, gene 1
XB-GENE-854726
548375
Zebrafish
ZDB-GENE-050626-142
574009
Species
Name
OMA
EggNOG
Inparanoid
Anole lizard
alkaline phosphatase, intestinal
Xenopus
alkaline phosphatase, intestinal, gene 1
Zebrafish
Publication Statistics
PubMed Score 173.37
PubMed score by year
PubTator Score 619.99
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title