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Tchem
ALPG
Alkaline phosphatase, germ cell type

Protein Summary
Description
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The product of this gene is a membrane bound glycosylated enzyme, localized to testis, thymus and certain germ cell tumors, that is closely related to both the placental and intestinal forms of alkaline phosphatase. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295453
  • ENSP00000295453
  • ENSG00000163286

Symbol
  • ALPPL
  • ALPPL2
  • GCAP
  • ALPPL
  • ALPPL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.62
protein domain
0.58
disease
0.55
gene perturbation
0.53
cellular component
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 165.46   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 165.46   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (136)
ALPP
Tbio
Family:  Enzyme
Novelty:  0.0037276
p_int:  1
Score:  0.873
Data Source:  BioPlex,STRINGDB
USP16
Tbio
Family:  Enzyme
Novelty:  0.13211126
p_int:  1
Score:  0.214
Data Source:  BioPlex,STRINGDB
ALPI
Tchem
Family:  Enzyme
Novelty:  0.00559196
p_int:  0.999999981
p_ni:  1.9e-8
Score:  0.968
Data Source:  BioPlex,STRINGDB
PCOLCE2
Tbio
Family:  Enzyme
Novelty:  0.13084379
p_int:  0.96433163
p_ni:  0.03548892
p_wrong:  0.00017945
Score:  0.23
Data Source:  BioPlex,STRINGDB
B3GLCT
Tbio
Family:  Enzyme
Novelty:  0.02398944
p_int:  0.957147212
p_ni:  0.042852788
Score:  0.243
Data Source:  BioPlex,STRINGDB
GALNS
Tbio
Family:  Enzyme
Novelty:  0.00510529
p_int:  0.919686168
p_ni:  0.080313832
Score:  0.481
Data Source:  BioPlex,STRINGDB
AHNAK
Tbio
Novelty:  0.01201996
p_int:  0.849279055
p_ni:  0.15072094
p_wrong:  5e-9
Score:  0.158
Data Source:  BioPlex,STRINGDB
THY1
Tbio
Novelty:  0.00032846
Score:  0.922
Data Source:  STRINGDB
PTS
Tbio
Family:  Enzyme
Novelty:  0.00279396
Score:  0.917
Data Source:  STRINGDB
CEACAM5
Tbio
Novelty:  0.00007291
Score:  0.913
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
3
3
83.7
BMI-adjusted waist circumference
3
8
9
82
BMI-adjusted hip circumference
1
4
4
52.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
3
83.7
BMI-adjusted waist circumference
9
82
BMI-adjusted hip circumference
4
52.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 165.46
PubMed score by year
PubTator Score 90.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title