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Tbio
ALOXE3
Hydroperoxide isomerase ALOXE3

Protein Summary
Description
Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced dioxygenase activity compared to other lipoxygenases. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols. The dioxygenase activity requires a step of activation of the enzyme by molecular oxygen. In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides. In the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. In parallel, it may have a signaling fu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318227
  • ENSP00000314879
  • ENSG00000179148
  • ENST00000448843
  • ENSP00000400581

Symbol
  • ARCI3
  • E-LOX
  • eLOX3
  • eLOX-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
transcription factor binding site profile
0.88
kinase perturbation
0.84
transcription factor
0.62
biological process
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.1   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 150   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.1   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
NBEA
Tbio
Novelty:  0.02583687
p_int:  0.99999995
p_ni:  6e-9
p_wrong:  4.4e-8
Score:  0.169
Data Source:  BioPlex,STRINGDB
ZFHX4
Tbio
Family:  TF
Novelty:  0.06538087
p_int:  0.999864414
p_ni:  0.000092254
p_wrong:  0.000043332
Score:  0.235
Data Source:  BioPlex,STRINGDB
DNAAF2
Tbio
Novelty:  0.01254416
p_int:  0.999712301
p_ni:  0.000287686
p_wrong:  1.3e-8
Data Source:  BioPlex
BEX5
Tdark
Novelty:  0.2964824
p_int:  0.989599214
p_ni:  0.010400546
p_wrong:  2.4e-7
Data Source:  BioPlex
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
p_int:  0.981406783
p_ni:  0.007540474
p_wrong:  0.011052743
Data Source:  BioPlex
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.97795644
p_ni:  0.02204356
Score:  0.16
Data Source:  BioPlex,STRINGDB
NDUFS5
Tclin
Family:  Enzyme
Novelty:  0.13274675
p_int:  0.965914088
p_ni:  0.034074939
p_wrong:  0.000010973
Data Source:  BioPlex
CCDC27
Tdark
Novelty:  1.27912281
p_int:  0.940825079
p_ni:  0.05891971
p_wrong:  0.000255211
Score:  0.189
Data Source:  BioPlex,STRINGDB
ZSCAN12
Tdark
Family:  TF
Novelty:  0.33578207
p_int:  0.910993659
p_ni:  0.089006324
p_wrong:  1.7e-8
Data Source:  BioPlex
EDEM3
Tbio
Family:  Enzyme
Novelty:  0.09828323
p_int:  0.891863873
p_ni:  0.108136127
Score:  0.187
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Synthesis of 12-eicosatetraenoic acid derivatives
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Fatty acid metabolism
Metabolism
Metabolism of lipids
Synthesis of 12-eicosatetraenoic acid derivatives
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
3
2
1.1
88.6
diastolic blood pressure
1
1
1
49.5
high density lipoprotein cholesterol measurement
1
1
1
49.5
apolipoprotein A 1 measurement
1
1
1
13.5
body height
1
1
1
11.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
1.1
88.6
diastolic blood pressure
1
49.5
high density lipoprotein cholesterol measurement
1
49.5
apolipoprotein A 1 measurement
1
13.5
body height
1
11.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
arachidonate lipoxygenase 3
VGNC:9140
455102
Macaque
arachidonate lipoxygenase 3
716840
Mouse
MGI:1345140
23801
Rat
RGD:1306252
287424
Dog
arachidonate lipoxygenase 3
VGNC:37814
489487
Species
Name
OMA
EggNOG
Inparanoid
Chimp
arachidonate lipoxygenase 3
Macaque
arachidonate lipoxygenase 3
Mouse
Rat
Dog
arachidonate lipoxygenase 3
Publication Statistics
PubMed Score 39.10
PubMed score by year
PubTator Score 26.27
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title