ALOX15
Arachidonate 15-lipoxygenase
Protein Summary
Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12-HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function through r ...more
- ENST00000293761
- ENSP00000293761
- ENSG00000161905
- ENST00000570836
- ENSP00000458832
- ENST00000574640
- ENSP00000460483
- LOG15
- LOG15
- 12-LOX
- 15-LOX
- 15-LOX-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.96 | ||
protein domain | 0.92 | ||
biological term | 0.91 | ||
molecular function | 0.91 | ||
chemical | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 610.61 (req: < 5)
Gene RIFs: 150 (req: <= 3)
Antibodies: 302 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 610.61 (req: >= 5)
Gene RIFs: 150 (req: > 3)
Antibodies: 302 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 30
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 171
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (2)
Active Ligands (171)
Protein-Protein Interactions (85)
DDX19B
Family: Enzyme
Novelty: 0.0504568
p_int: 0.999795164
p_ni: 0.000204836
Score: 0.19
Data Source: BioPlex,STRINGDB
TIMM29
Novelty: 0.51321672
p_int: 0.959908687
p_ni: 0.037997653
p_wrong: 0.002093659
Score: 0.214
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (4)
Upstream (1)
Downstream (3)
1 – 1 of 1
Pathways (34)
Reactome (21)
KEGG (6)
PathwayCommons (3)
UniProt (1)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Arachidonic acid metabolism | ||||
Reactome | Biosynthesis of DHA-derived SPMs | ||||
Reactome | Biosynthesis of DPA-derived SPMs | ||||
Reactome | Biosynthesis of DPAn-3 SPMs | ||||
Reactome | Biosynthesis of DPAn-3-derived protectins and resolvins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Arachidonic acid metabolism | ||||
Biosynthesis of DHA-derived SPMs | ||||
Biosynthesis of DPA-derived SPMs | ||||
Biosynthesis of DPAn-3 SPMs | ||||
Biosynthesis of DPAn-3-derived protectins and resolvins | ||||
Viral Interactions (0)
Gene Ontology Terms (35)
Functions (7)
Components (5)
Processes (23)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (20)
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
eosinophil count | 5 | 7 | 10 | 99.3 | |||||
eosinophil percentage of leukocytes | 2 | 7 | 8 | 99.1 | |||||
lymphocyte count | 3 | 3 | 3 | 93.2 | |||||
sum of eosinophil and basophil counts | 1 | 3 | 3 | 93 | |||||
eosinophil percentage of granulocytes | 1 | 2 | 2 | 86.2 | |||||
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
eosinophil count | 10 | 99.3 | |||||
eosinophil percentage of leukocytes | 8 | 99.1 | |||||
lymphocyte count | 3 | 93.2 | |||||
sum of eosinophil and basophil counts | 3 | 93 | |||||
eosinophil percentage of granulocytes | 2 | 86.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | arachidonate 15-lipoxygenase | VGNC:9149 | 748294 | |||||
Macaque | arachidonate 15-lipoxygenase | 709212 | ||||||
Mouse | MGI:87997 | 11687 | ||||||
Rat | RGD:70493 | 81639 | ||||||
Dog | arachidonate 15-lipoxygenase | VGNC:37811 | 489458 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | arachidonate 15-lipoxygenase | |||||
Macaque | arachidonate 15-lipoxygenase | |||||
Mouse | ||||||
Rat | ||||||
Dog | arachidonate 15-lipoxygenase | |||||
Publication Statistics
PubMed Score 610.61
PubMed score by year
PubTator Score 596.20
PubTator score by year
Related Publications
Text Mined References (192)
GeneRif Annotations (150)
Items per page:
0 of 0
PMID | Year | Title |
|---|