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Tchem
ALOX15
Arachidonate 15-lipoxygenase

Protein Summary
Description
Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12-HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function through r ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293761
  • ENSP00000293761
  • ENSG00000161905
  • ENST00000570836
  • ENSP00000458832
  • ENST00000574640
  • ENSP00000460483

Symbol
  • LOG15
  • LOG15
  • 12-LOX
  • 15-LOX
  • 15-LOX-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.96
protein domain
0.92
biological term
0.91
molecular function
0.91
chemical
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 610.61   (req: < 5)
Gene RIFs: 150   (req: <= 3)
Antibodies: 302   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 610.61   (req: >= 5)
Gene RIFs: 150   (req: > 3)
Antibodies: 302   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 171
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (171)
nordihydroguiaretic acid
Rendered image for nordihydroguiaretic acid
CHEMBL3290441
Rendered image for CHEMBL3290441
Caffeic acid Phenethyl Ester
Rendered image for Caffeic acid Phenethyl Ester
baicalein
Rendered image for baicalein
1-Phenyl-pyrazolidin-3-one
Rendered image for 1-Phenyl-pyrazolidin-3-one
CHEMBL235920
Rendered image for CHEMBL235920
jaspaquinol
Rendered image for jaspaquinol
puupehenone
Rendered image for puupehenone
CHEMBL3604174
Rendered image for CHEMBL3604174
CHEMBL314941
Rendered image for CHEMBL314941
Protein-Protein Interactions (85)
DDX19B
Tbio
Family:  Enzyme
Novelty:  0.0504568
p_int:  0.999795164
p_ni:  0.000204836
Score:  0.19
Data Source:  BioPlex,STRINGDB
TIMM29
Tdark
Novelty:  0.51321672
p_int:  0.959908687
p_ni:  0.037997653
p_wrong:  0.002093659
Score:  0.214
Data Source:  BioPlex,STRINGDB
IL4
Tbio
Novelty:  0.00005852
Score:  0.972
Data Source:  STRINGDB
IL13
Tbio
Novelty:  0.00021435
Score:  0.965
Data Source:  STRINGDB
PTGS2
Tclin
Family:  Enzyme
Novelty:  0.00007089
Score:  0.959
Data Source:  STRINGDB
PTGS1
Tclin
Family:  Enzyme
Novelty:  0.00043214
Score:  0.958
Data Source:  STRINGDB
CYP2B6
Tchem
Novelty:  0.00018351
Score:  0.932
Data Source:  STRINGDB
CYP2J2
Tchem
Novelty:  0.00534181
Score:  0.929
Data Source:  STRINGDB
CYP4F3
Tbio
Family:  Enzyme
Novelty:  0.01392719
Score:  0.926
Data Source:  STRINGDB
CYP2C9
Tchem
Novelty:  0.00041914
Score:  0.922
Data Source:  STRINGDB
Pathways (34)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Biosynthesis of DHA-derived SPMs
Reactome
Biosynthesis of DPA-derived SPMs
Reactome
Biosynthesis of DPAn-3 SPMs
Reactome
Biosynthesis of DPAn-3-derived protectins and resolvins
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Biosynthesis of DHA-derived SPMs
Biosynthesis of DPA-derived SPMs
Biosynthesis of DPAn-3 SPMs
Biosynthesis of DPAn-3-derived protectins and resolvins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (35)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
5
7
10
99.3
eosinophil percentage of leukocytes
2
7
8
99.1
lymphocyte count
3
3
3
93.2
sum of eosinophil and basophil counts
1
3
3
93
eosinophil percentage of granulocytes
1
2
2
86.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
10
99.3
eosinophil percentage of leukocytes
8
99.1
lymphocyte count
3
93.2
sum of eosinophil and basophil counts
3
93
eosinophil percentage of granulocytes
2
86.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
arachidonate 15-lipoxygenase
VGNC:9149
748294
Macaque
arachidonate 15-lipoxygenase
709212
Mouse
MGI:87997
11687
Rat
RGD:70493
81639
Dog
arachidonate 15-lipoxygenase
VGNC:37811
489458
Species
Name
OMA
EggNOG
Inparanoid
Chimp
arachidonate 15-lipoxygenase
Macaque
arachidonate 15-lipoxygenase
Mouse
Rat
Dog
arachidonate 15-lipoxygenase
Publication Statistics
PubMed Score 610.61
PubMed score by year
PubTator Score 596.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title