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Tchem
ALOX15
Arachidonate 15-lipoxygenase

Protein Summary
Description
Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12-HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function through r ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293761
  • ENSP00000293761
  • ENSG00000161905
  • ENST00000570836
  • ENSP00000458832
  • ENST00000574640
  • ENSP00000460483

Symbol
  • LOG15
  • LOG15
  • 12-LOX
  • 15-LOX
  • 15-LOX-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.96
protein domain
0.92
biological term
0.91
molecular function
0.91
chemical
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 675.04   (req: < 5)
Gene RIFs: 150   (req: <= 3)
Antibodies: 302   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 675.04   (req: >= 5)
Gene RIFs: 150   (req: > 3)
Antibodies: 302   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 171
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2