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Tchem
ALOX12
Arachidonate 12-lipoxygenase, 12S-type

Protein Summary
Description
Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation. This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on different polyun ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251535
  • ENSP00000251535
  • ENSG00000108839

Symbol
  • 12LO
  • LOG12
  • LOG12
  • 12-LOX
  • 12S-LOX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
protein domain
0.92
biological term
0.77
disease
0.73
molecular function
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 357.67   (req: < 5)
Gene RIFs: 92   (req: <= 3)
Antibodies: 214   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 357.67   (req: >= 5)
Gene RIFs: 92   (req: > 3)
Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 44
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (44)
nordihydroguiaretic acid
Rendered image for nordihydroguiaretic acid
baicalein
Rendered image for baicalein
1-Phenyl-pyrazolidin-3-one
Rendered image for 1-Phenyl-pyrazolidin-3-one
SID4253947
Rendered image for SID4253947
alpha-mangostin
Rendered image for alpha-mangostin
CHEMBL333219
Rendered image for CHEMBL333219
Fisetin
Rendered image for Fisetin
CHEMBL314941
Rendered image for CHEMBL314941
CHEMBL89283
Rendered image for CHEMBL89283
Protein-Protein Interactions (87)
PTGS1
Tclin
Family:  Enzyme
Novelty:  0.00043214
Score:  0.958
Data Source:  STRINGDB
PTGS2
Tclin
Family:  Enzyme
Novelty:  0.00007089
Score:  0.951
Data Source:  STRINGDB
CYP4F3
Tbio
Family:  Enzyme
Novelty:  0.01392719
Score:  0.928
Data Source:  STRINGDB
CYP2B6
Tchem
Novelty:  0.00018351
Score:  0.926
Data Source:  STRINGDB
CYP2J2
Tchem
Novelty:  0.00534181
Score:  0.921
Data Source:  STRINGDB
CYP4F2
Tchem
Family:  Enzyme
Novelty:  0.0050361
Score:  0.917
Data Source:  STRINGDB
CYP4A11
Tbio
Novelty:  0.01121493
Score:  0.915
Data Source:  STRINGDB
CYP2C9
Tchem
Novelty:  0.00041914
Score:  0.915
Data Source:  STRINGDB
ALOX5
Tclin
Family:  Enzyme
Novelty:  0.00062988
Score:  0.912
Data Source:  STRINGDB
ALOX15B
Tchem
Family:  Enzyme
Novelty:  0.01578108
Score:  0.912
Data Source:  STRINGDB
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
1 – 3 of 3
Pathways (23)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Biosynthesis of DHA-derived SPMs
Reactome
Biosynthesis of DPA-derived SPMs
Reactome
Biosynthesis of DPAn-3 SPMs
Reactome
Biosynthesis of DPAn-3-derived maresins
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Biosynthesis of DHA-derived SPMs
Biosynthesis of DPA-derived SPMs
Biosynthesis of DPAn-3 SPMs
Biosynthesis of DPAn-3-derived maresins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
8
2
1.2
93.1
blood metabolite measurement
1
1
1
75.7
total cholesterol measurement
1
1
1
74.4
body height
1
1
1
56.8
alkaline phosphatase measurement
1
1
1
43.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.2
93.1
blood metabolite measurement
1
75.7
total cholesterol measurement
1
74.4
body height
1
56.8
alkaline phosphatase measurement
1
43.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
arachidonate 12-lipoxygenase, 12S type
VGNC:12026
455242
Macaque
arachidonate 12-lipoxygenase, 12S type
713748
Mouse
MGI:87998
11684
Rat
RGD:1311159
287454
Dog
arachidonate 12-lipoxygenase, 12S type
VGNC:49900
479476
Species
Name
OMA
EggNOG
Inparanoid
Chimp
arachidonate 12-lipoxygenase, 12S type
Macaque
arachidonate 12-lipoxygenase, 12S type
Mouse
Rat
Dog
arachidonate 12-lipoxygenase, 12S type
Publication Statistics
PubMed Score 357.67
PubMed score by year
PubTator Score 102.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title