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Tbio
ALKBH7
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial

Protein Summary
Description
May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate (PubMed:25122757). Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death (PubMed:23666923). ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage (PubMed:23666923). Does not display DNA demethylase activity (PubMed:23666923). Involved in fatty acid metabolism (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000245812
  • ENSP00000245812
  • ENSG00000125652

Symbol
  • ABH7
  • SPATA11
  • ABH7
  • SPATA11
  • UNQ6002
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.76
transcription factor binding site profile
0.61
cell type or tissue
0.58
interacting protein
0.49
small molecule perturbation
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.09   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 67   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.09   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (28)
NDUFS7
Tclin
Family:  Enzyme
Novelty:  0.01562198
p_int:  0.999986598
p_ni:  1.52e-7
p_wrong:  0.00001325
Score:  0.332
Data Source:  BioPlex,STRINGDB
ALKBH6
Tdark
Family:  Enzyme
Novelty:  0.37634837
Score:  0.902
Data Source:  STRINGDB
JMJD4
Tbio
Novelty:  0.09951585
Score:  0.9
Data Source:  STRINGDB
ALKBH1
Tbio
Family:  Enzyme
Novelty:  0.00504781
Score:  0.884
Data Source:  STRINGDB
ALKBH4
Tbio
Family:  Enzyme
Novelty:  0.34513259
Score:  0.876
Data Source:  STRINGDB
ALKBH8
Tbio
Novelty:  0.02797162
Score:  0.864
Data Source:  STRINGDB
NDUFB7
Tclin
Family:  Enzyme
Novelty:  0.14580093
Score:  0.773
Data Source:  STRINGDB
ALKBH3
Tchem
Family:  Enzyme
Novelty:  0.02040675
Score:  0.699
Data Source:  STRINGDB
ALKBH2
Tbio
Family:  Enzyme
Novelty:  0.02318716
Score:  0.697
Data Source:  STRINGDB
NDUFS8
Tclin
Family:  Enzyme
Novelty:  0.02408724
Score:  0.69
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
alkB homolog 7
VGNC:2362
740313
Macaque
alkB homolog 7
699343
Mouse
MGI:1913650
66400
Rat
RGD:1598126
679944
Dog
alkB homolog 7
VGNC:37807
611351
Species
Name
OMA
EggNOG
Inparanoid
Chimp
alkB homolog 7
Macaque
alkB homolog 7
Mouse
Rat
Dog
alkB homolog 7
Publication Statistics
PubMed Score 9.09
PubMed score by year
PubTator Score 4.33
PubTator score by year
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Related Publications
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PMID
Year
Title