Tbio ALKBH4 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4

Protein Summary

Description

Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes. Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. May be involved in transcription regulation.

Uniprot Accession IDs

• Q9NXW9
• Q53H92
• Q9H6A4

Gene Name

• ALKBH4

Ensembl ID

• ENST00000292566
• ENSP00000292566
• ENSG00000160993
• ENST00000490528
• ENSP00000420362

Symbol

• ABH4
• ABH4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.84
transcription factor binding site profile	0.67
kinase perturbation	0.66
transcription factor	0.64
small molecule perturbation	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.32   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 139   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.32   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0