You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ALG5
Dolichyl-phosphate beta-glucosyltransferase

Protein Summary
Description
This gene encodes a member of the glycosyltransferase 2 family. The encoded protein participates in glucosylation of the oligomannose core in N-linked glycosylation of proteins. The addition of glucose residues to the oligomannose core is necessary to ensure substrate recognition, and therefore, effectual transfer of the oligomannose core to the nascent glycoproteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000239891
  • ENSP00000239891
  • ENSG00000120697
  • ENST00000443765
  • ENSP00000390533

Symbol
  • bA421P11.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
disease perturbation
0.79
transcription factor binding site profile
0.77
virus perturbation
0.76
gene perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.22   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.22   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (97)
CACNG1
Tbio
Family:  IC
Novelty:  0.11899252
p_int:  0.999726941
p_ni:  0.000273059
Data Source:  BioPlex
EDA
Tbio
Novelty:  0.00352464
p_int:  0.993849841
p_ni:  0.006150159
Data Source:  BioPlex
PKD2
Tchem
Family:  IC
Novelty:  0.00305329
p_int:  0.986772933
p_ni:  0.013223708
p_wrong:  0.000003359
Score:  0.211
Data Source:  BioPlex,STRINGDB
ADCY9
Tbio
Family:  Enzyme
Novelty:  0.00744116
p_int:  0.972232334
p_ni:  0.027767666
Data Source:  BioPlex
PVR
Tbio
Novelty:  0.00215811
p_int:  0.958624366
p_ni:  0.041375634
Data Source:  BioPlex
LSMEM2
Tdark
Novelty:  43
p_int:  0.947985197
p_ni:  0.052014803
Data Source:  BioPlex
TMEM63A
Tdark
Family:  IC
Novelty:  0.33131011
p_int:  0.93350396
p_ni:  0.066496034
p_wrong:  6e-9
Score:  0.409
Data Source:  BioPlex,STRINGDB
SLC1A5
Tchem
Family:  Transporter
Novelty:  0.00201741
p_int:  0.931895236
p_ni:  0.068104764
Score:  0.158
Data Source:  BioPlex,STRINGDB
DLK2
Tbio
Novelty:  0.06366405
p_int:  0.921957672
p_ni:  0.078042328
Score:  0.158
Data Source:  BioPlex,STRINGDB
PCDHGB1
Tdark
Novelty:  0.60440805
p_int:  0.917101485
p_ni:  0.082898515
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Synthesis of dolichyl-phosphate-glucose
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Metabolism of proteins
Post-translational protein modification
Synthesis of dolichyl-phosphate-glucose
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
3
4
81.5
1
1
0
1.1
46.9
bone density
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
81.5
0
1.1
46.9
bone density
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ALG5, dolichyl-phosphate beta-glucosyltransferase
VGNC:13064
452541
Macaque
ALG5, dolichyl-phosphate beta-glucosyltransferase
694836
Mouse
MGI:1913498
66248
Rat
RGD:1308900
295051
Dog
ALG5, dolichyl-phosphate beta-glucosyltransferase
VGNC:37799
477301
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ALG5, dolichyl-phosphate beta-glucosyltransferase
Macaque
ALG5, dolichyl-phosphate beta-glucosyltransferase
Mouse
Rat
Dog
ALG5, dolichyl-phosphate beta-glucosyltransferase
Publication Statistics
PubMed Score 24.22
PubMed score by year
PubTator Score 4.32
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title