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Tbio
ALG13
Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13

Protein Summary
Description
Isoform 1: Possible multifunctional enzyme with both glycosyltransferase and deubiquitinase activities. Isoform 2: May be involved in protein N-glycosylation, second step of the dolichol-linked oligosaccharide pathway. The protein encoded by this gene is a subunit of a bipartite UDP-N-acetylglucosamine transferase. It heterodimerizes with asparagine-linked glycosylation 14 homolog to form a functional UDP-GlcNAc glycosyltransferase that catalyzes the second sugar addition of the highly conserved oligosaccharide precursor in endoplasmic reticulum N-linked glycosylation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251943
  • ENSP00000251943
  • ENSG00000101901
  • ENST00000371979
  • ENSP00000361047
  • ENST00000394780
  • ENSP00000378260
  • ENST00000436609
  • ENSP00000392990
  • ENST00000610588
  • ENSP00000479731
  • ENST00000621367
  • ENSP00000481509

Symbol
  • CXorf45
  • GLT28D1
  • CDG1S
  • EIEE36
  • MDS031
  • TDRD13
  • CXorf45
  • GLT28D1
  • YGL047W
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.77
kinase perturbation
0.76
virus perturbation
0.72
cell type or tissue
0.69
transcription factor perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.73   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 153   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.73   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0