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Tbio
ALG12
Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase

Protein Summary
Description
Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation. This gene encodes a member of the glycosyltransferase 22 family. The encoded protein catalyzes the addition of the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation. Mutations in this gene have been associated with congenital disorder of glycosylation type Ig (CDG-Ig)characterized by abnormal N-glycosylation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330817
  • ENSP00000333813
  • ENSG00000182858

Symbol
  • CDG1G
  • ECM39
  • hALG12
  • PP14673
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
small molecule perturbation
0.67
cell line
0.65
cellular component
0.64
tissue sample
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.17   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.17   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (88)
TCTN2
Tbio
Novelty:  0.11617528
p_int:  0.999831275
p_ni:  0.000168725
Data Source:  BioPlex
MPPE1
Tbio
Family:  Enzyme
Novelty:  0.16027847
p_int:  0.998921678
p_ni:  0.001050169
p_wrong:  0.000028153
Score:  0.252
Data Source:  BioPlex,STRINGDB
GGT7
Tbio
Family:  Enzyme
Novelty:  0.01374716
p_int:  0.991826762
p_ni:  0.006622988
p_wrong:  0.001550251
Score:  0.169
Data Source:  BioPlex,STRINGDB
WDR4
Tbio
Family:  Enzyme
Novelty:  0.06887397
p_int:  0.9548395
p_ni:  0.00064984
p_wrong:  0.04451066
Score:  0.261
Data Source:  BioPlex,STRINGDB
ASIC4
Tbio
Family:  IC
Novelty:  0.02912816
p_int:  0.914628793
p_ni:  0.000815883
p_wrong:  0.084555324
Data Source:  BioPlex
SLC39A12
Tbio
Family:  Transporter
Novelty:  0.09127395
p_int:  0.849619137
p_ni:  0.000614592
p_wrong:  0.149766271
Data Source:  BioPlex
PI4K2A
Tbio
Family:  Kinase
Novelty:  0.03506675
p_int:  0.802158552
p_ni:  0.000144245
p_wrong:  0.197697203
Data Source:  BioPlex
NUP35
Tbio
Novelty:  0.0355102
p_int:  0.756819486
p_ni:  0.243180514
Score:  0.189
Data Source:  BioPlex,STRINGDB
ALG9
Tbio
Family:  Enzyme
Novelty:  0.02975572
Score:  0.995
Data Source:  STRINGDB
ALG3
Tbio
Family:  Enzyme
Novelty:  0.0159047
Score:  0.975
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Defective ALG12 causes ALG12-CDG (CDG-1g)
Reactome
Disease
Reactome
Diseases associated with N-glycosylation of proteins
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Defective ALG12 causes ALG12-CDG (CDG-1g)
Disease
Diseases associated with N-glycosylation of proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
4
2
1
86.6
mean platelet volume
2
2
2
80.4
platelet count
1
1
1
70.5
heel bone mineral density
2
2
2
68.8
sex hormone-binding globulin measurement
4
3
6
65.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
86.6
mean platelet volume
2
80.4
platelet count
1
70.5
heel bone mineral density
2
68.8
sex hormone-binding globulin measurement
6
65.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ALG12, alpha-1,6-mannosyltransferase
VGNC:9921
470247
Macaque
ALG12, alpha-1,6-mannosyltransferase
715172
Mouse
MGI:2385025
223774
Rat
RGD:1304826
315212
Dog
ALG12, alpha-1,6-mannosyltransferase
VGNC:37795
481196
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ALG12, alpha-1,6-mannosyltransferase
Macaque
ALG12, alpha-1,6-mannosyltransferase
Mouse
Rat
Dog
ALG12, alpha-1,6-mannosyltransferase
Publication Statistics
PubMed Score 29.17
PubMed score by year
PubTator Score 8.12
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title