ALG12
Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
histone modification site profile | 0.88 | ||
small molecule perturbation | 0.67 | ||
cell line | 0.65 | ||
cellular component | 0.64 | ||
tissue sample | 0.62 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Asparagine N-linked glycosylation | ||||
Reactome | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | ||||
Reactome | Defective ALG12 causes ALG12-CDG (CDG-1g) | ||||
Reactome | Disease | ||||
Reactome | Diseases associated with N-glycosylation of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Asparagine N-linked glycosylation | ||||
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | ||||
Defective ALG12 causes ALG12-CDG (CDG-1g) | ||||
Disease | ||||
Diseases associated with N-glycosylation of proteins | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
5 | 4 | 2 | 1 | 86.6 | |||||
mean platelet volume | 2 | 2 | 2 | 80.4 | |||||
platelet count | 1 | 1 | 1 | 70.5 | |||||
heel bone mineral density | 2 | 2 | 2 | 68.8 | |||||
sex hormone-binding globulin measurement | 4 | 3 | 6 | 65.6 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
2 | 1 | 86.6 | |||||
mean platelet volume | 2 | 80.4 | |||||
platelet count | 1 | 70.5 | |||||
heel bone mineral density | 2 | 68.8 | |||||
sex hormone-binding globulin measurement | 6 | 65.6 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | ALG12, alpha-1,6-mannosyltransferase | VGNC:9921 | 470247 | |||||
Macaque | ALG12, alpha-1,6-mannosyltransferase | 715172 | ||||||
Mouse | MGI:2385025 | 223774 | ||||||
Rat | RGD:1304826 | 315212 | ||||||
Dog | ALG12, alpha-1,6-mannosyltransferase | VGNC:37795 | 481196 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | ALG12, alpha-1,6-mannosyltransferase | |||||
Macaque | ALG12, alpha-1,6-mannosyltransferase | |||||
Mouse | ||||||
Rat | ||||||
Dog | ALG12, alpha-1,6-mannosyltransferase | |||||
PMID | Year | Title |
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