You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ALDOA
Fructose-bisphosphate aldolase A

Protein Summary
Description
Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity). This gene encodes a member of the class I fructose-bisphosphate aldolase protein family. The encoded protein is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Mutations in this gene have been associated with Glycogen Storage Disease XII, an autosomal recessive disorder associated with hemolytic anemia. Disruption of this gene also plays a role in the progression of multiple types of cancers. Related pseudogenes have been identified on chromosomes 3 and 10. [provided by RefSeq, Sep 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000412304
  • ENSP00000400452
  • ENSG00000149925
  • ENST00000563060
  • ENSP00000455800
  • ENST00000564546
  • ENSP00000455917
  • ENST00000564595
  • ENSP00000457468
  • ENST00000569545
  • ENSP00000455700
  • ENST00000642816
  • ENSP00000496166
  • ENST00000643777
  • ENSP00000494188

Symbol
  • ALDA
  • ALDA
  • GSD12
  • HEL-S-87p
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
1
interacting protein
0.99
transcription factor perturbation
0.99
disease perturbation
0.98
transcription factor
0.97


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 247.02   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 632   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 247.02   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 632   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0