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Tchem
ALDH1B1
Aldehyde dehydrogenase X, mitochondrial

Protein Summary
Description
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. This gene does not contain introns in the coding sequence. The variation of this locus may affect the development of alcohol-related problems. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377698
  • ENSP00000366927
  • ENSG00000137124

Symbol
  • ALDH5
  • ALDHX
  • ALDH5
  • ALDHX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.98
protein domain
0.85
histone modification site profile
0.82
pathway
0.75
PubMedID
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.91   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 258   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.91   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 258   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (97)
FEM1B
Tbio
Novelty:  0.06746412
p_int:  0.989282236
p_ni:  0.010717761
p_wrong:  4e-9
Score:  0.249
Data Source:  BioPlex,STRINGDB
DHRS4
Tbio
Family:  Enzyme
Novelty:  0.02992279
p_int:  0.947545192
p_ni:  0.05245437
p_wrong:  4.38e-7
Score:  0.349
Data Source:  BioPlex,STRINGDB
SUFU
Tbio
Novelty:  0.00475249
p_int:  0.893246933
p_ni:  0.106752248
p_wrong:  8.19e-7
Score:  0.226
Data Source:  BioPlex,STRINGDB
HIBADH
Tbio
Family:  Enzyme
Novelty:  0.03861647
Score:  0.956
Data Source:  STRINGDB
ABAT
Tclin
Family:  Enzyme
Novelty:  0.0078359
Score:  0.942
Data Source:  STRINGDB
AKR1A1
Tchem
Family:  Enzyme
Novelty:  0.0054436
Score:  0.933
Data Source:  STRINGDB
ALDH6A1
Tbio
Family:  Enzyme
Novelty:  0.03785268
Score:  0.931
Data Source:  STRINGDB
DERA
Tbio
Family:  Enzyme
Novelty:  0.0079635
Score:  0.927
Data Source:  STRINGDB
AOC1
Tchem
Family:  Enzyme
Novelty:  0.00146464
Score:  0.925
Data Source:  STRINGDB
BBOX1
Tchem
Family:  Enzyme
Novelty:  0.00255489
Score:  0.923
Data Source:  STRINGDB
Nearest Tclin Targets (13)
Explore Nearest Tclin Targets
Pathways (26)
Biological oxidations (R-HSA-211859)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Ethanol oxidation
Reactome
Metabolism
Reactome
Phase I - Functionalization of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Ethanol oxidation
Metabolism
Phase I - Functionalization of compounds
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aldehyde dehydrogenase 1 family member B1
VGNC:4609
464931
Macaque
aldehyde dehydrogenase 1 family member B1
716092
Mouse
MGI:1919785
72535
Rat
RGD:1306737
298079
Dog
aldehyde dehydrogenase 1 family member B1
VGNC:51696
481620
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aldehyde dehydrogenase 1 family member B1
Macaque
aldehyde dehydrogenase 1 family member B1
Mouse
Rat
Dog
aldehyde dehydrogenase 1 family member B1
Publication Statistics
PubMed Score 58.91
PubMed score by year
PubTator Score 23.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title