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Tchem
ALDH1A3
Aldehyde dehydrogenase family 1 member A3

Protein Summary
Description
NAD-dependent aldehyde dehydrogenase that catalyzes the formation of retinoic acid (PubMed:27759097). Has high activity with all-trans retinal, and has much lower in vitro activity with acetaldehyde (PubMed:27759097). Required for the biosynthesis of normal levels of retinoic acid in the embryonic ocular and nasal regions; retinoic acid is required for normal embryonic development of the eye and the nasal region (By similarity). This gene encodes an aldehyde dehydrogenase enzyme that uses retinal as a substrate. Mutations in this gene have been associated with microphthalmia, isolated 8, and expression changes have also been detected in tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329841
  • ENSP00000332256
  • ENSG00000184254

Symbol
  • ALDH6
  • ALDH6
  • MCOP8
  • RALDH3
  • ALDH1A6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.97
gene perturbation
0.95
molecular function
0.86
protein domain
0.85
small molecule perturbation
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 175.37   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 194   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 175.37   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 49
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0