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Tchem
ALDH1A2
Retinal dehydrogenase 2

Protein Summary
Description
Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently (By similarity). This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Four transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249750
  • ENSP00000249750
  • ENSG00000128918
  • ENST00000347587
  • ENSP00000309623
  • ENST00000537372
  • ENSP00000438296
  • ENST00000559517
  • ENSP00000453408

Symbol
  • RALDH2
  • RALDH2
  • RALDH2-T
  • RALDH(II)
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.94
PubMedID
0.88
gene perturbation
0.85
protein domain
0.85
phenotype
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 236.75   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 326   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 236.75   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 326   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 40
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 18
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (18)
CHEMBL4099822
Rendered image for CHEMBL4099822
CHEMBL1349972
Rendered image for CHEMBL1349972
CHEMBL4072941
Rendered image for CHEMBL4072941
CHEMBL4090473
Rendered image for CHEMBL4090473
CHEMBL3276621
Rendered image for CHEMBL3276621
CHEMBL4064364
Rendered image for CHEMBL4064364
CHEMBL1562069
Rendered image for CHEMBL1562069
CHEMBL4213331
Rendered image for CHEMBL4213331
CHEMBL4210115
Rendered image for CHEMBL4210115
CHEMBL4214509
Rendered image for CHEMBL4214509
Protein-Protein Interactions (124)
ALDH2
Tclin
Family:  Enzyme
Novelty:  0.00077122
p_int:  0.894939617
p_ni:  0.105060383
p_wrong:  1e-9
Score:  0.531
Data Source:  BioPlex,STRINGDB
MPZL1
Tbio
Novelty:  0.03292508
p_int:  0.823829302
p_ni:  0.176170698
Score:  0.187
Data Source:  BioPlex,STRINGDB
PRDX2
Tbio
Novelty:  0.00189751
p_int:  0.764722134
p_ni:  0.235277866
Score:  0.221
Data Source:  BioPlex,STRINGDB
CYP26A1
Tchem
Family:  Enzyme
Novelty:  0.00281805
Score:  0.991
Data Source:  STRINGDB
CYP26B1
Tchem
Novelty:  0.00990332
Score:  0.978
Data Source:  STRINGDB
CYP26C1
Tbio
Novelty:  0.04960237
Score:  0.964
Data Source:  STRINGDB
RDH11
Tbio
Family:  Enzyme
Novelty:  0.02758936
Score:  0.962
Data Source:  STRINGDB
RDH12
Tbio
Family:  Enzyme
Novelty:  0.016003
Score:  0.958
Data Source:  STRINGDB
RDH5
Tbio
Family:  Enzyme
Novelty:  0.0111079
Score:  0.954
Data Source:  STRINGDB
DHRS3
Tbio
Family:  Enzyme
Novelty:  0.04448013
Score:  0.951
Data Source:  STRINGDB
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
1 – 3 of 3
ADH1A
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
ADH1B
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
ADH1C
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
Pathways (18)
RA biosynthesis pathway (R-HSA-5365859)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
RA biosynthesis pathway
Reactome
Signal Transduction
Reactome
Signaling by Nuclear Receptors
Reactome
Signaling by Retinoic Acid
Name
Explore in Pharos
Explore in Source
RA biosynthesis pathway
Signal Transduction
Signaling by Nuclear Receptors
Signaling by Retinoic Acid
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (43)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (51)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
35
59
126
2.3
100
apolipoprotein A 1 measurement
2
37
38
100
total cholesterol measurement
11
31
50
2.6
99.4
triglyceride measurement
22
21
58
3.3
99.4
sleep duration
3
11
13
99.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
126
2.3
100
apolipoprotein A 1 measurement
38
100
total cholesterol measurement
50
2.6
99.4
triglyceride measurement
58
3.3
99.4
sleep duration
13
99.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aldehyde dehydrogenase 1 family member A2
VGNC:3517
746847
Macaque
aldehyde dehydrogenase 1 family member A2
702235
Mouse
MGI:107928
19378
Rat
RGD:620250
116676
Dog
aldehyde dehydrogenase 1 family member A2
VGNC:37783
478319
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aldehyde dehydrogenase 1 family member A2
Macaque
aldehyde dehydrogenase 1 family member A2
Mouse
Rat
Dog
aldehyde dehydrogenase 1 family member A2
Publication Statistics
PubMed Score 236.75
PubMed score by year
PubTator Score 79.29
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title