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Tbio
ALDH16A1
Aldehyde dehydrogenase family 16 member A1

Protein Summary
Description
This gene encodes a member of the aldehyde dehydrogenase superfamily. The family members act on aldehyde substrates and use nicotinamide adenine dinucleotide phosphate (NADP) as a cofactor. This gene is conserved in chimpanzee, dog, cow, mouse, rat, and zebrafish. The protein encoded by this gene interacts with maspardin, a protein that when truncated is responsible for Mast syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293350
  • ENSP00000293350
  • ENSG00000161618
  • ENST00000455361
  • ENSP00000410142
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
kinase perturbation
0.71
transcription factor binding site profile
0.71
transcription factor perturbation
0.61
cell line
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.26   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 94   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.26   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (55)
PCMT1
Tbio
Family:  Enzyme
Novelty:  0.01414946
p_int:  0.999997676
p_ni:  0.000002324
Score:  0.171
Data Source:  BioPlex,STRINGDB
LANCL1
Tbio
Novelty:  0.06479031
p_int:  0.999987159
p_ni:  0.000012841
Score:  0.228
Data Source:  BioPlex,STRINGDB
ERP29
Tbio
Novelty:  0.0132632
p_int:  0.999869135
p_ni:  0.000130865
Score:  0.211
Data Source:  BioPlex,STRINGDB
TLR1
Tbio
Novelty:  0.00171909
p_int:  0.99981277
p_ni:  0.000187227
p_wrong:  4e-9
Score:  0.228
Data Source:  BioPlex,STRINGDB
FAM117B
Tdark
Novelty:  1.06316483
p_int:  0.896530191
p_ni:  0.103469809
Score:  0.189
Data Source:  BioPlex,STRINGDB
ADD2
Tbio
Family:  Enzyme
Novelty:  0.01097975
p_int:  0.757178411
p_ni:  0.242821584
p_wrong:  5e-9
Score:  0.241
Data Source:  BioPlex,STRINGDB
ATXN7L1
Tdark
Novelty:  0.43694835
p_int:  0.755176077
p_ni:  0.244821454
p_wrong:  0.000002469
Data Source:  BioPlex
DERA
Tbio
Family:  Enzyme
Novelty:  0.0079635
Score:  0.951
Data Source:  STRINGDB
SPG21
Tbio
Family:  Enzyme
Novelty:  0.07929043
Score:  0.904
Data Source:  STRINGDB
ALDH18A1
Tbio
Family:  Enzyme
Novelty:  0.00301673
Score:  0.814
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (46)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
7
11
13
99.1
blood protein measurement
9
12
17
96.4
hematocrit
4
5
5
94.9
hemoglobin measurement
5
6
6
92.7
sex hormone-binding globulin measurement
8
2
7
6.3
91.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
13
99.1
blood protein measurement
17
96.4
hematocrit
5
94.9
hemoglobin measurement
6
92.7
sex hormone-binding globulin measurement
7
6.3
91.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aldehyde dehydrogenase 16 family member A1
VGNC:3661
468953
Mouse
MGI:1916998
69748
Rat
RGD:1566295
361571
Dog
aldehyde dehydrogenase 16 family member A1
VGNC:37780
610267
Horse
aldehyde dehydrogenase 16 family member A1
VGNC:15226
100055479
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aldehyde dehydrogenase 16 family member A1
Mouse
Rat
Dog
aldehyde dehydrogenase 16 family member A1
Horse
aldehyde dehydrogenase 16 family member A1
Publication Statistics
PubMed Score 5.26
PubMed score by year
PubTator Score 2.17
PubTator score by year
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Related Publications
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PMID
Year
Title