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Tbio
AKTIP
AKT-interacting protein

Protein Summary
Description
Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade. The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosp ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300245
  • ENSP00000300245
  • ENSG00000166971
  • ENST00000394657
  • ENSP00000378152
  • ENST00000570004
  • ENSP00000455874

Symbol
  • FTS
  • FT1
  • FTS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
virus perturbation
0.88
histone modification site profile
0.82
transcription factor binding site profile
0.78
kinase perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 319.53   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 252   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 319.53   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 252   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (84)
HOOK3
Tbio
Novelty:  0.0553474
p_int:  1
Score:  0.996
Data Source:  BioPlex,STRINGDB
FAM160A1
Tdark
Novelty:  2.71755347
p_int:  0.999999945
p_wrong:  5.5e-8
Score:  0.916
Data Source:  BioPlex,STRINGDB
FAM160A2
Tbio
Novelty:  1.08224895
p_int:  0.999999908
p_ni:  6e-9
p_wrong:  8.5e-8
Score:  0.995
Data Source:  BioPlex,STRINGDB
HOOK2
Tbio
Novelty:  0.03559628
p_int:  0.9999999
p_ni:  1e-7
Score:  0.979
Data Source:  BioPlex,STRINGDB
HOOK1
Tbio
Novelty:  0.04136856
p_int:  0.99999837
p_ni:  0.00000163
Score:  0.987
Data Source:  BioPlex,STRINGDB
TNFSF13B
Tclin
Novelty:  0.00069885
p_int:  0.999995337
p_ni:  0.000003954
p_wrong:  7.08e-7
Score:  0.759
Data Source:  BioPlex,STRINGDB
TRIM35
Tbio
Novelty:  0.03280419
p_int:  0.99991414
p_ni:  0.000072854
p_wrong:  0.000013006
Score:  0.203
Data Source:  BioPlex,STRINGDB
TSC1
Tbio
Novelty:  0.00406614
p_int:  0.999867388
p_ni:  0.000132588
p_wrong:  2.4e-8
Score:  0.336
Data Source:  BioPlex,STRINGDB
SYCE1
Tbio
Novelty:  0.05038876
p_int:  0.999756782
p_ni:  0.000001583
p_wrong:  0.000241635
Data Source:  BioPlex
NAB1
Tbio
Novelty:  0.03811946
p_int:  0.999010222
p_ni:  6.13e-7
p_wrong:  0.000989165
Score:  0.519
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Electronic Annotation (IEA)
GOC
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
3
5
6
89.9
intelligence
3
7
2
7
83.3
self reported educational attainment
2
2
2
80.6
BMI-adjusted waist-hip ratio
2
3
3
73.7
cognitive function measurement
3
1
3
73.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
6
89.9
intelligence
2
7
83.3
self reported educational attainment
2
80.6
BMI-adjusted waist-hip ratio
3
73.7
cognitive function measurement
3
73.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
AKT interacting protein
VGNC:5670
467979
Macaque
AKT interacting protein
697107
Mouse
MGI:3693832
14339
Rat
RGD:1311170
291906
Dog
AKT interacting protein
VGNC:37774
478126
Species
Name
OMA
EggNOG
Inparanoid
Chimp
AKT interacting protein
Macaque
AKT interacting protein
Mouse
Rat
Dog
AKT interacting protein
Publication Statistics
PubMed Score 319.53
PubMed score by year
PubTator Score 156.97
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title