You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
AKT3
RAC-gamma serine/threonine-protein kinase

Protein Summary
Description
AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis. The protein encoded by this gene i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263826
  • ENSP00000263826
  • ENSG00000117020
  • ENST00000336199
  • ENSP00000336943
  • ENST00000366539
  • ENSP00000355497
  • ENST00000366540
  • ENSP00000355498
  • ENST00000613395
  • ENSP00000479922
  • ENSG00000275199
  • ENST00000619536
  • ENSP00000483054
  • ENST00000621586
  • ENSP00000479081

Symbol
  • PKBG
  • MPPH
  • PKBG
  • MPPH2
  • PRKBG
  • STK-2
  • PKB-GAMMA
  • RAC-gamma
  • RAC-PK-gamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
transcription factor perturbation
0.94
molecular function
0.91
microRNA
0.89
pathway
0.88


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 342.97   (req: < 5)
Gene RIFs: 105   (req: <= 3)
Antibodies: 1054   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 342.97   (req: >= 5)
Gene RIFs: 105   (req: > 3)
Antibodies: 1054   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 102
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0