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Tchem
AKT2
RAC-beta serine/threonine-protein kinase

Protein Summary
Description
AKT2 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT regulates also the storage of glucose in the form of glycog ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311278
  • ENSP00000309428
  • ENSG00000105221
  • ENST00000392038
  • ENSP00000375892
  • ENST00000424901
  • ENSP00000399532

Symbol
  • PKBB
  • PRKBB
  • HIHGHH
  • PKBBETA
  • RAC-BETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
kinase perturbation
0.99
protein domain
0.99
transcription factor perturbation
0.98
hub protein
0.96


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 536.04   (req: < 5)
Gene RIFs: 206   (req: <= 3)
Antibodies: 1474   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 536.04   (req: >= 5)
Gene RIFs: 206   (req: > 3)
Antibodies: 1474   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 299
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (324)
AKT1
Tchem
Family:  Kinase
Novelty:  0.00003185
p_int:  1
Score:  0.983
Data Source:  BioPlex,STRINGDB
UBE2O
Tbio
Novelty:  0.07084123
p_int:  0.995490647
p_ni:  0.004509353
Score:  0.26
Data Source:  BioPlex,STRINGDB
CDK3
Tchem
Family:  Kinase
Novelty:  0.03380289
p_int:  0.992789696
p_ni:  0.007210304
Score:  0.324
Data Source:  BioPlex,STRINGDB
PSMD9
Tbio
Family:  Enzyme
Novelty:  0.02173534
p_int:  0.985642993
p_ni:  0.014353548
p_wrong:  0.000003459
Score:  0.46
Data Source:  BioPlex,STRINGDB
NR2F2
Tchem
Family:  NR
Novelty:  0.00450561
p_int:  0.983962529
p_ni:  0.014126854
p_wrong:  0.001910617
Score:  0.259
Data Source:  BioPlex,STRINGDB
TPM2
Tbio
Novelty:  0.00406572
p_int:  0.967586478
p_ni:  0.032413515
p_wrong:  7e-9
Score:  0.152
Data Source:  BioPlex,STRINGDB
USP9Y
Tdark
Family:  Enzyme
p_int:  0.922537469
p_ni:  0.077444644
p_wrong:  0.000017888
Data Source:  BioPlex
FAT3
Tbio
Novelty:  0.03661008
p_int:  0.9106543
p_ni:  0.0893457
Score:  0.204
Data Source:  BioPlex,STRINGDB
UBB
Tbio
Novelty:  0.00661254
p_int:  0.891843071
p_ni:  0.108156929
Score:  0.168
Data Source:  BioPlex,STRINGDB
NSMCE4A
Tdark
Novelty:  0.45550673
p_int:  0.778340111
p_ni:  0.212425301
p_wrong:  0.009234588
Score:  0.175
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (9)
Explore Nearest Tclin Targets
Pathways (262)
AKT phosphorylates targets in the cytosol (R-HSA-198323)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 87
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AKT phosphorylates targets in the cytosol
Reactome
AKT phosphorylates targets in the nucleus
Reactome
AKT-mediated inactivation of FOXO1A
Reactome
Activation of AKT2
Reactome
Activation of BAD and translocation to mitochondria
Name
Explore in Pharos
Explore in Source
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the nucleus
AKT-mediated inactivation of FOXO1A
Activation of AKT2
Activation of BAD and translocation to mitochondria
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
2
2
61.4
creatinine measurement
1
2
2
50.6
glomerular filtration rate
1
2
2
47.7
mean reticulocyte volume
1
1
1
42.3
diastolic blood pressure
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
61.4
creatinine measurement
2
50.6
glomerular filtration rate
2
47.7
mean reticulocyte volume
1
42.3
diastolic blood pressure
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
AKT serine/threonine kinase 2
VGNC:10908
456035
Macaque
AKT serine/threonine kinase 2
700591
Mouse
MGI:104874
11652
Rat
RGD:2082
25233
Dog
AKT serine/threonine kinase 2
VGNC:37772
449021
Species
Name
OMA
EggNOG
Inparanoid
Chimp
AKT serine/threonine kinase 2
Macaque
AKT serine/threonine kinase 2
Mouse
Rat
Dog
AKT serine/threonine kinase 2
Publication Statistics
PubMed Score 536.04
PubMed score by year
PubTator Score 382.72
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title