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Tbio
AKR1B15
Aldo-keto reductase family 1 member B15

Protein Summary
Description
Isoform 1: Mainly acts as a reductive enzyme that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. Has a strong selectivity towards NADP(H) (PubMed:25577493). Isoform 2: No oxidoreductase activity observed with the tested substrates.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000423958
  • ENSP00000397009
  • ENSG00000227471
  • ENST00000457545
  • ENSP00000389289

Symbol
  • AKR1B10L
  • AKR1R1B7
  • AKR1B10L, AK1R1B7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.75
protein domain
0.58
chemical
0.43
disease
0.41
biological term
0.35


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.3   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 7   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.3   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 7   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (24)
AKR1B10
Tchem
Family:  Enzyme
Novelty:  0.00533958
p_int:  0.999999999
p_ni:  1e-9
Score:  0.528
Data Source:  BioPlex,STRINGDB
AKR1B1
Tclin
Family:  Enzyme
Novelty:  0.00045769
p_int:  0.999929771
p_ni:  0.000070229
Score:  0.701
Data Source:  BioPlex,STRINGDB
ENO2
Tbio
Family:  Enzyme
Novelty:  0.00016748
Score:  0.889
Data Source:  STRINGDB
NME2
Tbio
Family:  Kinase
Novelty:  0.00257937
Score:  0.877
Data Source:  STRINGDB
STIP1
Tbio
Novelty:  0.00590952
Score:  0.835
Data Source:  STRINGDB
HINT1
Tchem
Novelty:  0.00815168
Score:  0.823
Data Source:  STRINGDB
ENO1
Tchem
Family:  Enzyme
Novelty:  0.00109178
Score:  0.731
Data Source:  STRINGDB
TKT
Tchem
Family:  Enzyme
Novelty:  0.00333936
Score:  0.65
Data Source:  STRINGDB
GLO1
Tchem
Family:  Enzyme
Novelty:  0.00225012
Score:  0.64
Data Source:  STRINGDB
KCNAB3
Tbio
Family:  IC
Novelty:  0.10128237
Score:  0.596
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Estrogen biosynthesis (R-HSA-193144)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Estrogen biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroid hormones
Reactome
Metabolism of steroids
Name
Explore in Pharos
Explore in Source
Estrogen biosynthesis
Metabolism
Metabolism of lipids
Metabolism of steroid hormones
Metabolism of steroids
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
1
1
61.4
Agents acting on the renin-angiotensin system use measurement
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
61.4
Agents acting on the renin-angiotensin system use measurement
1
39.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aldo-keto reductase family 1 member B15
VGNC:50817
736853
Mouse
MGI:107673
14187
Cow
aldo-keto reductase family 1 member B10
525193
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aldo-keto reductase family 1 member B15
Mouse
Cow
aldo-keto reductase family 1 member B10
Publication Statistics
PubMed Score 4.30
PubMed score by year
PubTator Score 2.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title